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Genome-wide characterization of the routes to pluripotency

Overview of attention for article published in Nature, December 2014
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (98th percentile)
  • Good Attention Score compared to outputs of the same age and source (65th percentile)

Mentioned by

news
6 news outlets
blogs
3 blogs
twitter
24 tweeters
patent
2 patents
peer_reviews
1 peer review site
weibo
11 weibo users
facebook
5 Facebook pages
googleplus
1 Google+ user
q&a
1 Q&A thread

Citations

dimensions_citation
103 Dimensions

Readers on

mendeley
532 Mendeley
citeulike
4 CiteULike
Title
Genome-wide characterization of the routes to pluripotency
Published in
Nature, December 2014
DOI 10.1038/nature14046
Pubmed ID
Authors

Samer M. I. Hussein, Mira C. Puri, Peter D. Tonge, Marco Benevento, Andrew J. Corso, Jennifer L. Clancy, Rowland Mosbergen, Mira Li, Dong-Sung Lee, Nicole Cloonan, David L. A. Wood, Javier Munoz, Robert Middleton, Othmar Korn, Hardip R. Patel, Carl A. White, Jong-Yeon Shin, Maely E. Gauthier, Kim-Anh Lê Cao, Jong-Il Kim, Jessica C. Mar, Nika Shakiba, William Ritchie, John E. J. Rasko, Sean M. Grimmond, Peter W. Zandstra, Christine A. Wells, Thomas Preiss, Jeong-Sun Seo, Albert J. R. Heck, Ian M. Rogers, Andras Nagy

Abstract

Somatic cell reprogramming to a pluripotent state continues to challenge many of our assumptions about cellular specification, and despite major efforts, we lack a complete molecular characterization of the reprograming process. To address this gap in knowledge, we generated extensive transcriptomic, epigenomic and proteomic data sets describing the reprogramming routes leading from mouse embryonic fibroblasts to induced pluripotency. Through integrative analysis, we reveal that cells transition through distinct gene expression and epigenetic signatures and bifurcate towards reprogramming transgene-dependent and -independent stable pluripotent states. Early transcriptional events, driven by high levels of reprogramming transcription factor expression, are associated with widespread loss of histone H3 lysine 27 (H3K27me3) trimethylation, representing a general opening of the chromatin state. Maintenance of high transgene levels leads to re-acquisition of H3K27me3 and a stable pluripotent state that is alternative to the embryonic stem cell (ESC)-like fate. Lowering transgene levels at an intermediate phase, however, guides the process to the acquisition of ESC-like chromatin and DNA methylation signature. Our data provide a comprehensive molecular description of the reprogramming routes and is accessible through the Project Grandiose portal at http://www.stemformatics.org.

Twitter Demographics

The data shown below were collected from the profiles of 24 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 532 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 10 2%
United Kingdom 4 <1%
Spain 3 <1%
France 3 <1%
Italy 2 <1%
Brazil 2 <1%
Australia 2 <1%
Turkey 2 <1%
Iran, Islamic Republic of 1 <1%
Other 8 2%
Unknown 495 93%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 147 28%
Researcher 135 25%
Student > Master 68 13%
Professor > Associate Professor 42 8%
Student > Bachelor 36 7%
Other 104 20%
Readers by discipline Count As %
Agricultural and Biological Sciences 294 55%
Biochemistry, Genetics and Molecular Biology 117 22%
Medicine and Dentistry 40 8%
Unspecified 24 5%
Neuroscience 10 2%
Other 47 9%

Attention Score in Context

This research output has an Altmetric Attention Score of 96. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 18 September 2018.
All research outputs
#139,275
of 12,302,005 outputs
Outputs from Nature
#11,077
of 62,561 outputs
Outputs of similar age
#3,474
of 271,022 outputs
Outputs of similar age from Nature
#307
of 887 outputs
Altmetric has tracked 12,302,005 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 62,561 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 73.8. This one has done well, scoring higher than 82% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 271,022 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 887 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 65% of its contemporaries.