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Prostate volume and implant configuration during 48 hours of temporary prostate brachytherapy: limited effect of oedema

Overview of attention for article published in Radiation Oncology, December 2014
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Title
Prostate volume and implant configuration during 48 hours of temporary prostate brachytherapy: limited effect of oedema
Published in
Radiation Oncology, December 2014
DOI 10.1186/s13014-014-0272-9
Pubmed ID
Authors

Anna M Dinkla, Bradley R Pieters, Kees Koedooder, Niek van Wieringen, Rob van der Laarse, Arjan Bel

Abstract

BackgroundIn pulsed-dose rate prostate brachytherapy the dose is delivered during 48 hours after implantation, making the treatment sensitive to oedematic effects possibly affecting dose delivery. The aim was to study changes in prostate volume during treatment by analysing catheter configurations on three subsequent scans.MethodsProstate expansion was determined for 19 patients from the change in spatial distribution of the implanted catheters, using three CT-scans: a planning CT (CT1) and two CTs after 24 and 48 hours (CT2, CT3). An additional 4 patients only received one repeat CT (after 24 hours). The mean radial distance (MRD) of all dwell positions to the geometric centre of all dwell positions used was calculated to evaluate volume changes. From three implanted markers changes in inter-marker distances were assessed. The relative shifts of all dwell positions were determined using catheter- and marker-based registrations. Wilcoxon signed-rank tests were performed to compare the results from the different time points.ResultsThe MRDs measured on the two repeat CTs were significantly different from CT1. The mean prostate volume change derived from the difference in MRD was +4.3% (range ¿9.3% to +15.6%) for CT1-CT2 (p¿<¿.05) and +4.4% (range ¿7.5% to +16.3%) for CT1-CT3 (p¿<¿.05). These values represented a mean increase of 1.2 cm3 in the first 24 hours and 1.5 cm3 in the subsequent 24 hours. There was no clear sign of prostate expansion from the change in inter-marker distance (CT1-CT2: 0.2¿±¿1.8 mm; CT1-CT3: 0.6¿±¿2.2 mm). Catheter configuration remained stable; shifts in catheter positions were largest in the C-C direction: 0¿±¿1.8 mm for CT1-CT2 and 0¿±¿1.4 mm for CT2-CT3.ConclusionsThe volume changes derived from catheter displacements were small and therefore considered clinically insignificant. Implant configuration remains stable during 2 days of treatment, confirming the safety of this technique.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 15 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 15 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 3 20%
Student > Bachelor 2 13%
Researcher 2 13%
Student > Ph. D. Student 2 13%
Lecturer > Senior Lecturer 1 7%
Other 2 13%
Unknown 3 20%
Readers by discipline Count As %
Medicine and Dentistry 4 27%
Engineering 2 13%
Physics and Astronomy 2 13%
Psychology 1 7%
Computer Science 1 7%
Other 0 0%
Unknown 5 33%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 December 2014.
All research outputs
#20,246,428
of 22,774,233 outputs
Outputs from Radiation Oncology
#1,675
of 2,050 outputs
Outputs of similar age
#302,440
of 361,188 outputs
Outputs of similar age from Radiation Oncology
#68
of 86 outputs
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