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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Identification of immunodominant antigens in canine leptospirosis by Multi-Antigen Print ImmunoAssay (MAPIA)
|
|---|---|
| Published in |
BMC Veterinary Research, December 2014
|
| DOI | 10.1186/s12917-014-0288-2 |
| Pubmed ID | |
| Authors |
Sabrina Thomé, Carolina Lessa-Aquino, Albert Icksang Ko, Walter Lilenbaum, Marco Alberto Medeiros |
| Abstract |
BackgroundThe microscopic agglutination test (MAT), the standard method for serological diagnosis of leptospirosis, may present limitations regarding its sensitivity. Current studies suggest that Leptospira immunoglobulin-like (Lig) proteins and LipL32 are of particular interest as serodiagnostic markers since they are present only in pathogenic species of the Leptospira genus. The purpose of this study was to identify leptospiral immunodominant proteins that are recognized by canine sera from diseased dogs.ResultsA total of 109 dogs were studied, including seroreactive dogs (MAT ¿800) and dogs with no seroreactivity detectable by MAT. Eight recombinant fragments (31¿70 kDa) of pathogenic Leptospira were tested for their use as diagnostic markers for canine leptospirosis using the Multi-antigen Print Immunoassay (MAPIA) platform: LigB [582-947aa] from L. interrogans serovar Pomona, L. interrogans serovar Copenhageni and L. kirschneri serovar Gryppotyphosa, LigB [131-649aa] from L. interrogans serovar Copenhageni, L. interrogans serovar Canicola and L. kirschneri serovar Gryppotyphosa, LigA [625-1224aa] L. interrogans serovar Copenhageni and LipL32 from L. interrogans serovar Copenhageni. The data were analyzed and ROC curves were generated. Altogether, LigB [131-649aa] L. interrogans Canicola, LigB [131-649aa] L. kirschneri Gryppotyphosa and LipL32 L. interrogans Copenhageni showed best accuracy (AUC¿=¿0.826 to 0.869), with 70% specificity and sensitivity ranging from 89% to 95%.ConclusionsThese results reinforce their potential as diagnostic candidates for the development of new methods for the serological diagnosis of canine leptospirosis. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 2 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 224 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Brazil | 6 | 3% |
| India | 1 | <1% |
| Unknown | 217 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 55 | 25% |
| Student > Postgraduate | 27 | 12% |
| Student > Doctoral Student | 25 | 11% |
| Student > Bachelor | 24 | 11% |
| Student > Ph. D. Student | 14 | 6% |
| Other | 35 | 16% |
| Unknown | 44 | 20% |
| Readers by discipline | Count | As % |
|---|---|---|
| Veterinary Science and Veterinary Medicine | 70 | 31% |
| Agricultural and Biological Sciences | 48 | 21% |
| Medicine and Dentistry | 29 | 13% |
| Biochemistry, Genetics and Molecular Biology | 7 | 3% |
| Nursing and Health Professions | 3 | 1% |
| Other | 17 | 8% |
| Unknown | 50 | 22% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 11 December 2014.
All research outputs
#17,734,890
of 22,774,233 outputs
Outputs from BMC Veterinary Research
#1,675
of 3,045 outputs
Outputs of similar age
#247,386
of 360,902 outputs
Outputs of similar age from BMC Veterinary Research
#47
of 95 outputs
Altmetric has tracked 22,774,233 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,045 research outputs from this source. They receive a mean Attention Score of 3.8. This one is in the 37th percentile – i.e., 37% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 360,902 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 95 others from the same source and published within six weeks on either side of this one. This one is in the 41st percentile – i.e., 41% of its contemporaries scored the same or lower than it.