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Fasting: a major limitation for resistance exercise training effects in rodents

Overview of attention for article published in Brazilian Journal of Medical and Biological Research, January 2018
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Title
Fasting: a major limitation for resistance exercise training effects in rodents
Published in
Brazilian Journal of Medical and Biological Research, January 2018
DOI 10.1590/1414-431x20175427
Pubmed ID
Authors

W. das Neves, L.F. de Oliveira, R.P. da Silva, C.R.R. Alves, A.H. Lancha Jr.

Abstract

Protocols that mimic resistance exercise training (RET) in rodents present several limitations, one of them being the electrical stimulus, which is beyond the physiological context observed in humans. Recently, our group developed a conditioning system device that does not use electric shock to stimulate rats, but includes fasting periods before each RET session. The current study was designed to test whether cumulative fasting periods have some influence on skeletal muscle mass and function. Three sets of male Wistar rats were used in the current study. The first set of rats was submitted to a RET protocol without food restriction. However, rats were not able to perform exercise properly. The second and third sets were then randomly assigned into three experimental groups: 1) untrained control rats, 2) untrained rats submitted to fasting periods, and 3) rats submitted to RET including fasting periods before each RET session. While the second set of rats performed a short RET protocol (i.e., an adaptation protocol for 3 weeks), the third set of rats performed a longer RET protocol including overload (i.e., 8 weeks). After the short-term protocol, cumulative fasting periods promoted loss of weight (P<0.001). After the longer RET protocol, no difference was observed for body mass, extensor digitorum longus (EDL) morphology or skeletal muscle function (P>0.05 for all). Despite no effects on EDL mass, soleus muscle displayed significant atrophy in the fasting experimental groups (P<0.01). Altogether, these data indicate that fasting is a major limitation for RET in rats.

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Geographical breakdown

Country Count As %
Unknown 30 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 6 20%
Student > Ph. D. Student 4 13%
Student > Bachelor 3 10%
Student > Doctoral Student 2 7%
Other 2 7%
Other 5 17%
Unknown 8 27%
Readers by discipline Count As %
Nursing and Health Professions 5 17%
Biochemistry, Genetics and Molecular Biology 4 13%
Sports and Recreations 3 10%
Social Sciences 2 7%
Psychology 2 7%
Other 4 13%
Unknown 10 33%