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Parental DNA Methylation States Are Associated with Heterosis in Epigenetic Hybrids

Overview of attention for article published in Plant Physiology, December 2017
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (86th percentile)
  • Good Attention Score compared to outputs of the same age and source (74th percentile)

Mentioned by

blogs
1 blog
twitter
10 tweeters
facebook
1 Facebook page

Citations

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14 Dimensions

Readers on

mendeley
54 Mendeley
citeulike
1 CiteULike
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Title
Parental DNA Methylation States Are Associated with Heterosis in Epigenetic Hybrids
Published in
Plant Physiology, December 2017
DOI 10.1104/pp.17.01054
Pubmed ID
Authors

Kathrin Lauss, René Wardenaar, Rurika Oka, Marieke H. A. van Hulten, Victor Guryev, Joost J. B. Keurentjes, Maike Stam, Frank Johannes

Abstract

Despite the importance and wide exploitation of heterosis in commercial crop breeding, the molecular mechanisms behind this phenomenon are not completely understood. Recent studies have implicated changes in DNA methylation and small RNAs in hybrid performance, however, it remains unclear whether epigenetic changes are a cause or consequence of heterosis. Here, we analyze a large panel of over 500 A. thaliana epigenetic hybrid plants (epiHybrids), which we derived from near-isogenic but epigenetically divergent parents. This proof-of-principle experimental system allowed us to quantify the contribution of parental methylation differences to heterosis. We measured traits such as leaf area (LA), growth rate (GR), flowering time (FT), main stem branching (MSB), rosette branching (RB) and final plant height (HT) and observed several strong positive and negative heterotic phenotypes among the epiHybrids. Using an epigenetic quantitative trait locus mapping approach, we were able to identify specific differentially methylated regions (DMRs) in the parental genomes that are associated with hybrid performance. Sequencing of methylomes, transcriptomes and genomes of selected parent-epiHybrid combinations further showed that these parental DMRs most likely mediate remodeling of methylation and transcriptional states at specific loci in the hybrids. Taken together, our data suggest that locus-specific epigenetic divergence between the parental lines can directly or indirectly trigger heterosis in Arabidopsis hybrids independent of genetic changes. These results add to a growing body of evidence that points to epigenetic factors as one of the key determinants of hybrid performance.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 54 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 54 100%

Demographic breakdown

Readers by professional status Count As %
Unspecified 12 22%
Researcher 9 17%
Student > Ph. D. Student 8 15%
Student > Bachelor 7 13%
Student > Master 5 9%
Other 13 24%
Readers by discipline Count As %
Agricultural and Biological Sciences 29 54%
Unspecified 14 26%
Biochemistry, Genetics and Molecular Biology 10 19%
Social Sciences 1 2%

Attention Score in Context

This research output has an Altmetric Attention Score of 13. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 19 January 2018.
All research outputs
#1,030,937
of 12,387,983 outputs
Outputs from Plant Physiology
#450
of 8,514 outputs
Outputs of similar age
#46,798
of 358,521 outputs
Outputs of similar age from Plant Physiology
#50
of 199 outputs
Altmetric has tracked 12,387,983 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 91st percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 8,514 research outputs from this source. They receive a mean Attention Score of 4.9. This one has done particularly well, scoring higher than 94% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 358,521 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 86% of its contemporaries.
We're also able to compare this research output to 199 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.