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Premedication with dexmedetomidine in pediatric patients: a systematic review and meta-analysis

Overview of attention for article published in Clinics, December 2014
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Premedication with dexmedetomidine in pediatric patients: a systematic review and meta-analysis
Published in
Clinics, December 2014
DOI 10.6061/clinics/2014(11)12
Pubmed ID

K Peng, SR Wu, FH Ji, J Li


Premedication is important in pediatric anesthesia. This meta-analysis aimed to investigate the role of dexmedetomidine as a premedicant for pediatric patients. A systematic literature search was conducted to identify randomized controlled trials comparing dexmedetomidine premedication with midazolam or ketamine premedication or placebo in children. Two reviewers independently performed the study selection, quality assessment and data extraction. The original data were pooled for the meta-analysis with Review Manager 5. The main parameters investigated included satisfactory separation from parents, satisfactory mask induction, postoperative rescue analgesia, emergence agitation and postoperative nausea and vomiting. Thirteen randomized controlled trials involving 1190 patients were included. When compared with midazolam, premedication with dexmedetomidine resulted in an increase in satisfactory separation from parents (RD = 0.18, 95% CI: 0.06 to 0.30, p = 0.003) and a decrease in the use of postoperative rescue analgesia (RD = -0.19, 95% CI: -0.29 to -0.09, p = 0.0003). Children treated with dexmedetomidine had a lower heart rate before induction. The incidence of satisfactory mask induction, emergence agitation and PONV did not differ between the groups. Dexmedetomidine was superior in providing satisfactory intravenous cannulation compared to placebo. This meta-analysis suggests that dexmedetomidine is superior to midazolam premedication because it resulted in enhanced preoperative sedation and decreased postoperative pain. Additional studies are needed to evaluate the dosing schemes and long-term outcomes of dexmedetomidine premedication in pediatric anesthesia.

Mendeley readers

The data shown below were compiled from readership statistics for 127 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 <1%
Colombia 1 <1%
Unknown 125 98%

Demographic breakdown

Readers by professional status Count As %
Student > Master 22 17%
Student > Postgraduate 19 15%
Student > Bachelor 16 13%
Student > Ph. D. Student 10 8%
Student > Doctoral Student 8 6%
Other 28 22%
Unknown 24 19%
Readers by discipline Count As %
Medicine and Dentistry 76 60%
Nursing and Health Professions 9 7%
Psychology 4 3%
Pharmacology, Toxicology and Pharmaceutical Science 3 2%
Agricultural and Biological Sciences 2 2%
Other 6 5%
Unknown 27 21%