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Integrative analysis of high-throughput RNAi screen data identifies the FER and CRKL tyrosine kinases as new regulators of the mitogenic ERK-dependent pathways in transformed cells

Overview of attention for article published in BMC Genomics, December 2014
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Title
Integrative analysis of high-throughput RNAi screen data identifies the FER and CRKL tyrosine kinases as new regulators of the mitogenic ERK-dependent pathways in transformed cells
Published in
BMC Genomics, December 2014
DOI 10.1186/1471-2164-15-1169
Pubmed ID
Authors

Philippe Nizard, Frédéric Ezan, Dominique Bonnier, Nolwenn Le Meur, Sophie Langouët, Georges Baffet, Yannick Arlot-Bonnemains, Nathalie Théret

Abstract

Cell proliferation is a hallmark of cancer and depends on complex signaling networks that are chiefly supported by protein kinase activities. Therapeutic strategies have been used to target specific kinases but new methods are required to identify combined targets and improve treatment. Here, we propose a small interfering RNA genetic screen and an integrative approach to identify kinase networks involved in the proliferation of cancer cells.

X Demographics

X Demographics

The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 36 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Japan 1 3%
Canada 1 3%
Unknown 34 94%

Demographic breakdown

Readers by professional status Count As %
Student > Master 6 17%
Student > Bachelor 5 14%
Student > Ph. D. Student 5 14%
Student > Doctoral Student 4 11%
Researcher 3 8%
Other 5 14%
Unknown 8 22%
Readers by discipline Count As %
Agricultural and Biological Sciences 7 19%
Medicine and Dentistry 6 17%
Computer Science 4 11%
Biochemistry, Genetics and Molecular Biology 3 8%
Engineering 3 8%
Other 5 14%
Unknown 8 22%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 December 2014.
All research outputs
#17,735,364
of 22,775,504 outputs
Outputs from BMC Genomics
#7,555
of 10,642 outputs
Outputs of similar age
#241,617
of 352,833 outputs
Outputs of similar age from BMC Genomics
#180
of 253 outputs
Altmetric has tracked 22,775,504 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 10,642 research outputs from this source. They receive a mean Attention Score of 4.7. This one is in the 23rd percentile – i.e., 23% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 352,833 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 27th percentile – i.e., 27% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 253 others from the same source and published within six weeks on either side of this one. This one is in the 22nd percentile – i.e., 22% of its contemporaries scored the same or lower than it.