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The dynamic dimer structure of the chaperone Trigger Factor

Overview of attention for article published in Nature Communications, December 2017
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  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (96th percentile)
  • Good Attention Score compared to outputs of the same age and source (74th percentile)

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8 news outlets
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2 X users

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46 Dimensions

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Title
The dynamic dimer structure of the chaperone Trigger Factor
Published in
Nature Communications, December 2017
DOI 10.1038/s41467-017-02196-7
Pubmed ID
Authors

Leonor Morgado, Björn M. Burmann, Timothy Sharpe, Adam Mazur, Sebastian Hiller

Abstract

The chaperone Trigger Factor (TF) from Escherichia coli forms a dimer at cellular concentrations. While the monomer structure of TF is well known, the spatial arrangement of this dimeric chaperone storage form has remained unclear. Here, we determine its structure by a combination of high-resolution NMR spectroscopy and biophysical methods. TF forms a symmetric head-to-tail dimer, where the ribosome binding domain is in contact with the substrate binding domain, while the peptidyl-prolyl isomerase domain contributes only slightly to the dimer affinity. The dimer structure is highly dynamic, with the two ribosome binding domains populating a conformational ensemble in the center. These dynamics result from intermolecular in trans interactions of the TF client-binding site with the ribosome binding domain, which is conformationally frustrated in the absence of the ribosome. The avidity in the dimer structure explains how the dimeric state of TF can be monomerized also by weakly interacting clients.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 54 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 54 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 15 28%
Researcher 9 17%
Student > Bachelor 5 9%
Student > Postgraduate 3 6%
Student > Master 3 6%
Other 6 11%
Unknown 13 24%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 19 35%
Agricultural and Biological Sciences 7 13%
Chemistry 6 11%
Earth and Planetary Sciences 2 4%
Nursing and Health Professions 1 2%
Other 4 7%
Unknown 15 28%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 60. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 12 December 2017.
All research outputs
#605,444
of 23,011,300 outputs
Outputs from Nature Communications
#10,613
of 47,374 outputs
Outputs of similar age
#15,224
of 439,767 outputs
Outputs of similar age from Nature Communications
#364
of 1,436 outputs
Altmetric has tracked 23,011,300 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 97th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 47,374 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 55.9. This one has done well, scoring higher than 77% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 439,767 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 96% of its contemporaries.
We're also able to compare this research output to 1,436 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.