Immunonutrition as an adjuvant therapy for burns

Hannah B Tan, Stefan Danilla, Alexandra Murray, Ramón Serra, Regina El Dib, Tom Ow Henderson, Jason Wasiak, Tan HB, Danilla S, Murray A, Serra R, El Dib R, Henderson TO, Wasiak J

With burn injuries involving a large total body surface area (TBSA), the body can enter a state of breakdown, resulting in a condition similar to that seen with severe lack of proper nutrition. In addition, destruction of the effective skin barrier leads to loss of normal body temperature regulation and increased risk of infection and fluid loss. Nutritional support is common in the management of severe burn injury, and the approach of altering immune system activity with specific nutrients is termed immunonutrition. Three potential targets have been identified for immunonutrition: mucosal barrier function, cellular defence and local or systemic inflammation. The nutrients most often used for immunonutrition are glutamine, arginine, branched-chain amino acids (BCAAs), omega-3 (n-3) fatty acids and nucleotides.