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Distribution of allelic and genotypic frequencies of NAT2 and CYP2E1variants in Moroccan population

Overview of attention for article published in BMC Genetics, December 2014
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  • Above-average Attention Score compared to outputs of the same age (59th percentile)
  • Good Attention Score compared to outputs of the same age and source (75th percentile)

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Title
Distribution of allelic and genotypic frequencies of NAT2 and CYP2E1variants in Moroccan population
Published in
BMC Genetics, December 2014
DOI 10.1186/s12863-014-0156-x
Pubmed ID
Authors

Soukaina Guaoua, Ilham Ratbi, Fatima Zahra Laarabi, Siham Chafai Elalaoui, Imane Cherkaoui Jaouad, Amina Barkat, Abdelaziz Sefiani

Abstract

BackgroundSeveral pathogenesis and genetic factors influence predisposition to antituberculosis drug-induced hepatotoxicity (ATDH) especially for isoniazid (INH). However, the major susceptibility genes for ATDH are N-acetyltransferase 2 (NAT2) and cytochrome P450 2E1 (CYP2E1). NAT2 gene determines the individual¿s acetylator status (fast, intermediate or slow) to metabolize drugs and xenobiotics, while CYP2E1 c1/c1 genotype carriers had an increased risk of ATDH.Polymorphisms of the NAT2 and CYP2E1 genes vary remarkably among the populations of different ethnic origins.The aim of this study was to determine, for the first time, the frequency of slow acetylators in Moroccan population by genotyping of NAT2 gene variants and determining the genotype c1/c1 for CYP2E1 gene, in order to predict adverse effects of Tuberculosis treatment, particularly hepatotoxicity.ResultsThe frequencies of specific NAT2 alleles were 53%, 25%, 2% and 4% for NAT2*5, NAT2*6, NAT2*7 and NAT2*14 respectively among 163 Moroccan studied group. Genotyping of CYP2E1gene, by real-time polymerase chain reaction using TaqMan probes, revealed frequencies of 98.5% for c1/c1 and 1.5% for c1/c2 among 130 Moroccan studied group.ConclusionThe most prevalent genotypes of NAT2 gene in Moroccans are those which encode slow acetylation phenotype (72.39%), leading to a high risk of ATDH. Most Moroccans are homozygous for c1 allele of CYP2E1 gene which aggravates hepatotoxicity in slow acetylators.This genetic background should be taken into account in determining the minimum dose of INH needed to treat Moroccan TB patients, in order to decrease adverse effects.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 47 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Nigeria 1 2%
South Africa 1 2%
Unknown 45 96%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 9 19%
Student > Master 7 15%
Other 6 13%
Researcher 5 11%
Professor 4 9%
Other 8 17%
Unknown 8 17%
Readers by discipline Count As %
Medicine and Dentistry 15 32%
Biochemistry, Genetics and Molecular Biology 9 19%
Pharmacology, Toxicology and Pharmaceutical Science 5 11%
Agricultural and Biological Sciences 5 11%
Social Sciences 3 6%
Other 2 4%
Unknown 8 17%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 September 2016.
All research outputs
#6,706,581
of 12,372,276 outputs
Outputs from BMC Genetics
#301
of 828 outputs
Outputs of similar age
#104,740
of 272,679 outputs
Outputs of similar age from BMC Genetics
#18
of 69 outputs
Altmetric has tracked 12,372,276 research outputs across all sources so far. This one is in the 44th percentile – i.e., 44% of other outputs scored the same or lower than it.
So far Altmetric has tracked 828 research outputs from this source. They receive a mean Attention Score of 3.4. This one has gotten more attention than average, scoring higher than 61% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 272,679 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 59% of its contemporaries.
We're also able to compare this research output to 69 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 75% of its contemporaries.