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Mendeley readers
Attention Score in Context
| Title |
Comparison of growth factor adsorbed scaffold and conventional scaffold with growth factor supplemented media for primary human articular chondrocyte 3D culture
|
|---|---|
| Published in |
BMC Biotechnology, December 2014
|
| DOI | 10.1186/s12896-014-0108-6 |
| Pubmed ID | |
| Authors |
Jeerawan Klangjorhor, Thanyaluck Phitak, Dumnoensun Pruksakorn, Peraphan Pothacharoen, Prachya Kongtawelert |
| Abstract |
BackgroundCartilage tissue engineering offers new strategies in repairing damaged cartilage. Scaffolds have been used for the in vitro and in vivo procedures for this application, which demonstrates the compatible biological and physical properties that mimic natural tissues. Several types of scaffolds were used and had different effects on cell functions. The study was designed to develop a functional gelatin scaffold by adsorption of hyaluronan (HA) and the transforming growth factor ß3 (TGF-ß3) in a commercially available gelatin scaffold.ResultsThe biological properties of human articular chondrocytes were investigated during a 21-day cultivation embedded in either HA¿+¿TGF-ß3 adsorbed scaffolds or the conventional supplemented method. The rising of proliferation of chondrocytes embedded in adsorbed scaffolds was observed at day 17 and 21 of cultivation (1.27 and 1.28 fold, respectively). The chondrogenic gene expression of the chondrocytes embedded in HA¿+¿TGF-ß3 adsorbed scaffolds significantly increased: SOX-9 (1.65 fold), ACAN (7.65 fold) and COL2A1 (1.83 fold). Remarkably, over the 21 days of cultivation, HA¿+¿TGF-ß3 adsorbed scaffolds promoted the extracellular matrix molecules production with higher accumulation of HA (1.2 fold), collagen (1.42 fold) and uronic acid (1.41 fold). Moreover, the cell population and extracellular matrix production, which were examined by a histological analysis and a scanning electron microscope, were correlated with the biochemical analysis.ConclusionA small amount of HA and TGF-ß3 initially adsorbed in the scaffolds (70 ¿g and 10 ng, respectively) was consumed over the 21-day cultivation. The HA¿+¿TGF-ß3 adsorbed gelatin scaffold is effective and more suitable than the conventional supplemented method for the in vitro assessment of human chondrocyte 3D culture. |
Mendeley readers
The data shown below were compiled from readership statistics for 41 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Japan | 1 | 2% |
| Unknown | 40 | 98% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 6 | 15% |
| Researcher | 6 | 15% |
| Student > Master | 6 | 15% |
| Student > Bachelor | 3 | 7% |
| Student > Postgraduate | 3 | 7% |
| Other | 6 | 15% |
| Unknown | 11 | 27% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 7 | 17% |
| Engineering | 6 | 15% |
| Materials Science | 6 | 15% |
| Medicine and Dentistry | 6 | 15% |
| Biochemistry, Genetics and Molecular Biology | 4 | 10% |
| Other | 2 | 5% |
| Unknown | 10 | 24% |
Attention Score in Context
This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 December 2014.
All research outputs
#4,399,028
of 22,775,504 outputs
Outputs from BMC Biotechnology
#213
of 935 outputs
Outputs of similar age
#59,303
of 353,071 outputs
Outputs of similar age from BMC Biotechnology
#16
of 26 outputs
Altmetric has tracked 22,775,504 research outputs across all sources so far. Compared to these this one has done well and is in the 80th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 935 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 7.7. This one has gotten more attention than average, scoring higher than 73% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 353,071 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 82% of its contemporaries.
We're also able to compare this research output to 26 others from the same source and published within six weeks on either side of this one. This one is in the 7th percentile – i.e., 7% of its contemporaries scored the same or lower than it.