↓ Skip to main content

Expression pattern of NLRP3 and its related cytokines in the lung and brain of avian influenza virus H9N2 infected BALB/c mice

Overview of attention for article published in Virology Journal, December 2014
Altmetric Badge

About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (61st percentile)
  • Average Attention Score compared to outputs of the same age and source

Mentioned by

twitter
4 tweeters
facebook
2 Facebook pages

Citations

dimensions_citation
10 Dimensions

Readers on

mendeley
15 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Expression pattern of NLRP3 and its related cytokines in the lung and brain of avian influenza virus H9N2 infected BALB/c mice
Published in
Virology Journal, December 2014
DOI 10.1186/s12985-014-0229-5
Pubmed ID
Authors

Meng Yu, Kaizhao Zhang, Wenbao Qi, Zhiqiang Huang, Jinhui Ye, Yongjiang Ma, Ming Liao, Zhangyong Ning

Abstract

BackgroundH9N2 avian influenza virus (AIV) becomes the focus for its ability of transmission to mammals and as a donor to provide internal genes to form the new epidemic lethal influenza viruses. Residue 627 in PB2 has been proven the virulence factor of H9N2 avian influenza virus in mice, but the detailed data for inflammation difference between H9N2 virus strains with site 627 mutation is still unclear. The inflammasome NLRP3 is recently reported as the cellular machinery responsible for activation of inflammatory processes and plays an important role during the development of inflammation caused by influenza virus infection.MethodsIn this study, we investigated the expression pattern of NLRP3 and its related cytokines of IL-1ß and TNF-¿ in BALB/c mice infected by H9N2 AIV strains with only a site 627 difference at both mRNA and protein levels at different time points.ResultsThe results showed that the expression level of NLRP3, IL-1ß and TNF-¿ changed in the lung and brain of BALB/c mice after infection by VK627 and rVK627E. The immunohistological results showed that the positive cells of NLRP3, IL-1ß and TNF-¿ altered the positive levels of original cells in tissues and infiltrated inflammatory cells which caused by H9N2 infection.ConclusionsOur results provided the basic data at differences in expression pattern of NLRP3 and its related cytokines in BALB/c mice infected by H9N2 influenza viruses with only a site 627 difference. This implied that NLRP3 inflammasome plays a role in host response to influenza virus infection and determines the outcome of clinical manifestation and pathological injury. This will explain the variable of pathological presentation in tissues and enhance research on inflammation process of the AIV H9N2 infection.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 15 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 15 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 4 27%
Professor 3 20%
Student > Master 3 20%
Researcher 2 13%
Unspecified 2 13%
Other 1 7%
Readers by discipline Count As %
Agricultural and Biological Sciences 4 27%
Veterinary Science and Veterinary Medicine 3 20%
Medicine and Dentistry 3 20%
Unspecified 2 13%
Immunology and Microbiology 1 7%
Other 2 13%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 January 2015.
All research outputs
#1,911,831
of 4,739,474 outputs
Outputs from Virology Journal
#500
of 1,310 outputs
Outputs of similar age
#56,890
of 157,168 outputs
Outputs of similar age from Virology Journal
#45
of 69 outputs
Altmetric has tracked 4,739,474 research outputs across all sources so far. This one has received more attention than most of these and is in the 58th percentile.
So far Altmetric has tracked 1,310 research outputs from this source. They receive a mean Attention Score of 3.2. This one has gotten more attention than average, scoring higher than 59% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 157,168 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 61% of its contemporaries.
We're also able to compare this research output to 69 others from the same source and published within six weeks on either side of this one. This one is in the 31st percentile – i.e., 31% of its contemporaries scored the same or lower than it.