Title |
Resting state amygdala-prefrontal connectivity predicts symptom change after cognitive behavioral therapy in generalized social anxiety disorder
|
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Published in |
Biology of Mood & Anxiety Disorders, December 2014
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DOI | 10.1186/s13587-014-0014-5 |
Pubmed ID | |
Authors |
Heide Klumpp, Michael K Keutmann, Daniel A Fitzgerald, Stewart A Shankman, K Luan Phan |
Abstract |
Aberrant amygdala-prefrontal interactions at rest and during emotion processing are implicated in the pathophysiology of generalized social anxiety disorder (gSAD), a common disorder characterized by fears of potential scrutiny. Cognitive behavioral therapy (CBT) is first-line psychotherapy for gSAD and other anxiety disorders. While CBT is generally effective, there is a great deal of heterogeneity in treatment response. To date, predictors of success in CBT for gSAD include reduced amygdala reactivity and increased activity in prefrontal regulatory regions (e.g., anterior cingulate cortex, "ACC") during emotion processing. However, studies have not examined whether tonic (i.e., at rest) coupling of amygdala and these prefrontal regions also predict response to CBT. |
X Demographics
Geographical breakdown
Country | Count | As % |
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Germany | 1 | 50% |
United States | 1 | 50% |
Demographic breakdown
Type | Count | As % |
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Scientists | 1 | 50% |
Members of the public | 1 | 50% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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Germany | 3 | 2% |
Netherlands | 1 | <1% |
Canada | 1 | <1% |
Mexico | 1 | <1% |
Argentina | 1 | <1% |
Unknown | 135 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 31 | 22% |
Student > Ph. D. Student | 28 | 20% |
Student > Master | 18 | 13% |
Student > Bachelor | 12 | 8% |
Student > Doctoral Student | 9 | 6% |
Other | 19 | 13% |
Unknown | 25 | 18% |
Readers by discipline | Count | As % |
---|---|---|
Psychology | 62 | 44% |
Neuroscience | 18 | 13% |
Medicine and Dentistry | 9 | 6% |
Agricultural and Biological Sciences | 8 | 6% |
Nursing and Health Professions | 2 | 1% |
Other | 8 | 6% |
Unknown | 35 | 25% |