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Inhibition of matrix metalloproteinases attenuates brain damage in experimental meningococcal meningitis

Overview of attention for article published in BMC Infectious Diseases, December 2014
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Title
Inhibition of matrix metalloproteinases attenuates brain damage in experimental meningococcal meningitis
Published in
BMC Infectious Diseases, December 2014
DOI 10.1186/s12879-014-0726-6
Pubmed ID
Authors

Susanna Ricci, Denis Grandgirard, Michael Wenzel, Tiziana Braccini, Paola Salvatore, Marco R Oggioni, Stephen L Leib, Uwe Koedel

Abstract

BackgroundApproximately 7% of survivors from meningococcal meningitis (MM) suffer from neurological sequelae due to brain damage in the course of meningitis. The present study focuses on the role of matrix metalloproteinases (MMPs) in a novel mouse model of MM-induced brain damage.MethodsThe model is based on intracisternal infection of BALB/c mice with a serogroup C Neisseria meningitidis strain. Mice were infected with meningococci and randomised for treatment with the MMP inhibitor batimastat (BB-94) or vehicle. Animal survival, brain injury and host-response biomarkers were assessed 48 h after meningococcal challenge.ResultsMice that received BB-94 presented significantly diminished MMP-9 levels (p¿<¿0.01), intracerebral bleeding (p¿<¿0.01), and blood-brain barrier (BBB) breakdown (p¿<¿0.05) in comparison with untreated animals. In mice suffering from MM, the amount of MMP-9 measured by zymography significantly correlated with both intracerebral haemorrhage (p¿<¿0.01) and BBB disruption (p¿<¿0.05).ConclusionsMMPs significantly contribute to brain damage associated with experimental MM. Inhibition of MMPs reduces intracranial complications in mice suffering from MM, representing a potential adjuvant strategy in MM post-infection sequelae.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 22 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
China 1 5%
Switzerland 1 5%
Unknown 20 91%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 5 23%
Researcher 4 18%
Student > Postgraduate 3 14%
Student > Bachelor 2 9%
Student > Master 2 9%
Other 2 9%
Unknown 4 18%
Readers by discipline Count As %
Medicine and Dentistry 9 41%
Neuroscience 3 14%
Agricultural and Biological Sciences 2 9%
Immunology and Microbiology 1 5%
Sports and Recreations 1 5%
Other 1 5%
Unknown 5 23%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 October 2015.
All research outputs
#18,809,260
of 23,310,485 outputs
Outputs from BMC Infectious Diseases
#5,707
of 7,804 outputs
Outputs of similar age
#258,104
of 354,924 outputs
Outputs of similar age from BMC Infectious Diseases
#128
of 187 outputs
Altmetric has tracked 23,310,485 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 7,804 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 10.3. This one is in the 15th percentile – i.e., 15% of its peers scored the same or lower than it.
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We're also able to compare this research output to 187 others from the same source and published within six weeks on either side of this one. This one is in the 14th percentile – i.e., 14% of its contemporaries scored the same or lower than it.