Title |
Inhibition of matrix metalloproteinases attenuates brain damage in experimental meningococcal meningitis
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Published in |
BMC Infectious Diseases, December 2014
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DOI | 10.1186/s12879-014-0726-6 |
Pubmed ID | |
Authors |
Susanna Ricci, Denis Grandgirard, Michael Wenzel, Tiziana Braccini, Paola Salvatore, Marco R Oggioni, Stephen L Leib, Uwe Koedel |
Abstract |
BackgroundApproximately 7% of survivors from meningococcal meningitis (MM) suffer from neurological sequelae due to brain damage in the course of meningitis. The present study focuses on the role of matrix metalloproteinases (MMPs) in a novel mouse model of MM-induced brain damage.MethodsThe model is based on intracisternal infection of BALB/c mice with a serogroup C Neisseria meningitidis strain. Mice were infected with meningococci and randomised for treatment with the MMP inhibitor batimastat (BB-94) or vehicle. Animal survival, brain injury and host-response biomarkers were assessed 48 h after meningococcal challenge.ResultsMice that received BB-94 presented significantly diminished MMP-9 levels (p¿<¿0.01), intracerebral bleeding (p¿<¿0.01), and blood-brain barrier (BBB) breakdown (p¿<¿0.05) in comparison with untreated animals. In mice suffering from MM, the amount of MMP-9 measured by zymography significantly correlated with both intracerebral haemorrhage (p¿<¿0.01) and BBB disruption (p¿<¿0.05).ConclusionsMMPs significantly contribute to brain damage associated with experimental MM. Inhibition of MMPs reduces intracranial complications in mice suffering from MM, representing a potential adjuvant strategy in MM post-infection sequelae. |
X Demographics
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Unknown | 2 | 100% |
Demographic breakdown
Type | Count | As % |
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Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
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China | 1 | 5% |
Switzerland | 1 | 5% |
Unknown | 20 | 91% |
Demographic breakdown
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Student > Ph. D. Student | 5 | 23% |
Researcher | 4 | 18% |
Student > Postgraduate | 3 | 14% |
Student > Bachelor | 2 | 9% |
Student > Master | 2 | 9% |
Other | 2 | 9% |
Unknown | 4 | 18% |
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Medicine and Dentistry | 9 | 41% |
Neuroscience | 3 | 14% |
Agricultural and Biological Sciences | 2 | 9% |
Immunology and Microbiology | 1 | 5% |
Sports and Recreations | 1 | 5% |
Other | 1 | 5% |
Unknown | 5 | 23% |