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Just a quick comment from a pathologist's perspective- this paper focuses on esophageal squamous cell carcinoma, and the more common type in Asia you are referring to is actually adenocarcinoma (which…
Just a quick comment from a pathologist's perspective- this paper focuses on esophageal squamous cell carcinoma, and the more common type in Asia you are referring to is actually adenocarcinoma (which…
This article says cancer is not due to bad luck. http://www.cnbc.com/2016/05/20/half-of-us-cancer-deaths-due-to-bad-habits-study-finds...
Sir Percivall Pott's lecture is a colorful introduction for introductory epidemiology and toxicology textbooks, but the answer does not seem to be as simple as chimney sweeps in countries other than…
http://www.nature.com/nature/journal/v529/n7584/full/nature16166.html
http://www.bbc.co.uk/news/health-35111449
http://www.cnn.com/2015/12/17/health/cancer-not-due-to-bad-luck/index.html
The entire concept is of limited validity. Is the rate of cell division is different between races and or gender? Are breast cells in Oriental women divide slower than in Caucasian? Is stomach…
Science did not published any technical comment on this paper,prefering a collection of short letters. Open repositories fill-in the gap:http://biorxiv...
The International Agency for Research on Cancer (IARC), the World Health Organization’s specialized cancer agency, strongly disagrees with the conclusion of a scientific report1 on the causes of…
picking up the misinterpretations of the Tomasetti findings "We have found that the most frequent failure in data analysis is mistaking the type of question being considered"http://www...
Why? Vogelstein assumes a uniform mutation rate/stem cell division for all tissues. The important parameter in his model is the lifetime total number of stem cell divisions.
If I understood both papers correctly, the findings of this recent Nature paper (http://www.nature.com/nature/journal/vaop/ncurrent/full/nature14173...
Each cell-division introduces a risk of mutation. The risk of mutation per cell division can depend on many external factors. e.g. smoking greatly increases the risk of mutation in certain cells…
Miguel Lopez-Lazaro | Feb 25 2015 06:44 ESTCancer starts in our normal stem cells and develops through the accumulation of defects in these cells during their divisionThe study by Tomasetti and…
Daniel Corcos | Feb 06 2015 06:22 ESTIn the abstract of the paper, there is a wrong statement : « These results suggest that only a third of the variation in cancer risk among tissues is attributable…
nor a forum for character assassination, which permeates so many discussions.
Cyrille Delpierre | Feb 05 2015 11:43 ESTNo proof that cancer is mainly a random process C Delpierre, R Fantin, S Lamy, P Grosclaude, T Lang, M Kelly-IrvingTomasetti and Vogelstein (1) suggest in a…
Jim Brody | Feb 05 2015 14:20 ESTThe key paragraph in this paper is:"A linear correlation equal to 0.804 suggests that 65% (39% to 81%; 95% CI) of the differences in cancer risk among different…
The authors have posted a response to some of the comments on arXiv:http://arxiv.org/abs/1501.05035
Michele Ciulla | Feb 04 2015 04:12 ESTThe human side of randomness.The interest of the article by Tomasetti and Vogelstein (1) is mainly epistemological: can science, with its current setting, help…
The one in which Peer 3 gets cited :-)
A new arXiv paper destroys Fig 2 in the Vogelstein Cancer bad luck paper.http://arxiv.org/abs/1501.04605
Did the author of this blog read the paper to the last paragraph?Exerpt from this blog post: "some journalists have understood really wrong the message of the paper, publishing misguided headlines…
http://mappingignorance.org/2015/01/26/bad-luck-cancer/
Paolo Vineis | Jan 20 2015 05:41 ESTWe read Drs. Tomasetti and Vogelstein paper on the strong and positive association between the frequency of stem cell division and the risk of cancer with interest …
http://news.sciencemag.org/biology/2015/01/bad-luck-and-cancer-science-reporter-s-reflections-controversial-storyStill not a straight acknowledgement of the study's flaws discussed in this forum and…
Vladimir Kuznetsov | Jan 14 2015 20:14 ESTOne of the main hallmarks of cancer is uncontrolled cell proliferation, ultimately leading to the death of the multicellular organism...
Mark Burkitt | Jan 13 2015 10:16 ESTThe powerful correlation between the rate of stem cell proliferation and the incidence of cancer across a range of tissues, reported recently by Tomasetti and…
I think Pubpeer is not meant to be a scientific advertisement board
In reply to GEORGE BLANCK | Jan 09 2015 09:44 ESTI found that nearly unintelligible.
GEORGE BLANCK | Jan 09 2015 09:44 ESTStochastic aspects of cancer development:The article by Tomasetti and Vogelstein (1) has helped add another dimension to the study of cancer development, most…
Andrea Coletta | Jan 06 2015 05:45 ESTAs other commentators before me, I find hard to accept the authors conclusions.Although the clustering shows a larger number of cancer types (22 vs 9) for which…
I may have missed something but I see no justification for using the "extra risk factor" (ERF) defined as the product of the logs of the lifetime risk and number of stem cell divisions...
I have some doubt of the authors' analyses in this manuscript. In population genetics, setting heterozygosity H
The problem of the article is that it uses only cancer risk statistics from USA. Since the rates for many cancer types vary a lot between regions and countries, the correlation in fig...
http://1.usa.gov/1DaAIEl
Here is the link content:Vincent Detours 2015 Jan 05 10:59 a.m. No one denies that cancer initiation has a stochastic component, but the conclusion that "prevention measure are not likely to be…
Vincent Detours | Jan 05 2015 10:59 ESTNo one denies that cancer initiation has a stochastic component, but the conclusion that "prevention measure are not likely to be effective" for tumors arising…
http://www.sciencebasedmedicine.org/is-cancer-due-mostly-to-bad-luck/
http://www.ipscell.com/2015/01/review-of-vogelstein-bad-luck-cancer-stem-cell-paper-in-science/
Ah yes, the background of his comment is a little clearer now.Not to say that it his COI necessarily makes him wrong. Public guidelines on sun exposure have often been unclear and conflicting.
The estimation for the number of stem cell divisions is, in my opinion, highly speculative. Looking at how testicular stem cell divisions were calculated (my particular field of knowledge), there are…
Reply to Peer 2: ( January 4th, 2015 10:58pm UTC ). That jogs my memory from medical school days. It might have been during an introductory lecture on the causes of cancer...
The disclosure of Grant's potential conflicts of interest is useful. That's a benefit of PubMed Commons.
http://www.theguardian.com/science/grrlscientist/2015/jan/02/bad-luck-bad-journalism-and-cancer-rates
http://freethoughtblogs.com/pharyngula/2015/01/03/cancer-bad-genes-or-bad-luck/With this gem: "Chimney sweeps would get covered in the carcinogenic compounds present in soot, which would accumulate…
I'm not sure if comments get replicated on PubMed commons, but this comment illustrates some of the problems with turning cancer research into actionable advice that can be implemented by people...
William Grant | Jan 03 2015 11:13 ESTThe paper by Tomasetti and Vogelstein reported that variation in cancer risk among tissues can be explained by the number of stem cell divisions (1)...
http://ameyer.me/science/2015/01/02/vogel.html
Is this also bad luck?https://pubpeer.com/publications/876EA56A4549BCAA87455EA00E5A19
http://ameyer.me/science/2015/01/02/vogel.html