Title |
Astrocytes Protect Neurons from Aβ1-42Peptide-Induced Neurotoxicity Increasing TFAM and PGC-1 and Decreasing PPAR-γ and SIRT-1
|
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Published in |
International Journal of Medical Sciences, January 2015
|
DOI | 10.7150/ijms.10035 |
Pubmed ID | |
Authors |
Diana Aguirre-Rueda, Sol Guerra-Ojeda, Martin Aldasoro, Antonio Iradi, Elena Obrador, Angel Ortega, M. Dolores Mauricio, Jose Mª Vila, Soraya L. Valles |
Abstract |
One of the earliest neuropathological events in Alzheimer's disease is accumulation of astrocytes at sites of Aβ1-42 depositions. Our results indicate that Aβ1-42 toxic peptide increases lipid peroxidation, apoptosis and cell death in neurons but not in astrocytes in primary culture. Aβ1-42-induced deleterious neuronal effects are not present when neurons and astrocytes are mixed cultured. Stimulation of astrocytes with toxic Aβ1-42 peptide increased p-65 and decreased IκB resulting in inflammatory process. In astrocytes Aβ1-42 decreases protein expressions of sirtuin 1 (SIRT-1) and peroxisome proliferator-activated receptor γ (PPAR-γ) and over-expresses peroxisome proliferator-activated receptor γ coactivator 1 (PGC-1) and mitochondrial transcription factor A (TFAM), protecting mitochondria against Aβ1-42-induced damage and promoting mitochondrial biogenesis. In summary our data suggest that astrocytes may have a key role in protecting neurons, increasing neural viability and mitochondrial biogenesis, acquiring better oxidative stress protection and perhaps modulating inflammatory processes against Aβ1-42 toxic peptide. This might be a sign of a complex epigenetic process in Alzheimer's disease development. |
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Demographic breakdown
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Mendeley readers
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Unknown | 75 | 99% |
Demographic breakdown
Readers by professional status | Count | As % |
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Student > Ph. D. Student | 18 | 24% |
Researcher | 11 | 14% |
Student > Master | 8 | 11% |
Student > Bachelor | 7 | 9% |
Student > Doctoral Student | 5 | 7% |
Other | 8 | 11% |
Unknown | 19 | 25% |
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Biochemistry, Genetics and Molecular Biology | 7 | 9% |
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Medicine and Dentistry | 5 | 7% |
Other | 7 | 9% |
Unknown | 22 | 29% |