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Role of Drug Adsorption onto the Silica Surface in Drug Release from Mesoporous Silica Systems

Overview of attention for article published in Molecular Pharmaceutics, December 2017
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (82nd percentile)
  • High Attention Score compared to outputs of the same age and source (98th percentile)

Mentioned by

twitter
11 tweeters
patent
1 patent
facebook
1 Facebook page

Citations

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22 Dimensions

Readers on

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31 Mendeley
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Title
Role of Drug Adsorption onto the Silica Surface in Drug Release from Mesoporous Silica Systems
Published in
Molecular Pharmaceutics, December 2017
DOI 10.1021/acs.molpharmaceut.7b00778
Pubmed ID
Authors

Carol A. McCarthy, Robert J. Ahern, Ken J. Devine, Abina M. Crean

Abstract

Factors contributing to incomplete drug release from a number of mesoporous silica formulations are not well understood. This study aims to address this gap in knowledge by exploring the role of drug adsorption onto silica substrates during the drug release process in dissolution media. Adsorption isotherms were generated to understand drug adsorption behaviour onto the silica surface. Two silica materials were selected (SBA-15 (mesoporous) and Aerosil®200 (non-porous)) to investigate the influence of porous architecture on the adsorption/dissolution processes. The ability of the dissolution medium to wet the silica surface, particularly the porous network, was investigated by the addition of a surfactant to the dissolution medium. The results demonstrated that a larger amount of drug was bound/m2 to the non-porous surface than to the mesoporous material. Adsorption isotherms proved useful in understanding drug adsorption/release behaviour for the non-porous silica formulation. However, the quantity of drug remaining on the mesoporous silica surface after dissolution was significantly higher than the amount predicted using adsorption isotherm data. These results suggest that a fraction of loaded drug molecules were tightly bound to the silica surface or attached to sites which are inaccessible for the dissolution media. The presence of surfactant, sodium dodecyl sulphate, in the media enhanced drug release from the silica surface. This behaviour can be attributed to both the improved wetting characteristics of the media and adsorption of the surfactant to the silica surface. The findings of this study reinforce the significance of the role that silica porous architecture plays in the dissolution process and indicates that accessible surface area is an important parameter to consider for mesoporous systems in relation to drug release.

Twitter Demographics

The data shown below were collected from the profiles of 11 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 31 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 31 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 11 35%
Student > Master 8 26%
Researcher 3 10%
Student > Doctoral Student 1 3%
Lecturer 1 3%
Other 1 3%
Unknown 6 19%
Readers by discipline Count As %
Pharmacology, Toxicology and Pharmaceutical Science 11 35%
Chemistry 5 16%
Unspecified 2 6%
Biochemistry, Genetics and Molecular Biology 2 6%
Materials Science 2 6%
Other 2 6%
Unknown 7 23%

Attention Score in Context

This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 November 2020.
All research outputs
#2,557,684
of 19,496,717 outputs
Outputs from Molecular Pharmaceutics
#203
of 3,564 outputs
Outputs of similar age
#73,829
of 429,976 outputs
Outputs of similar age from Molecular Pharmaceutics
#3
of 113 outputs
Altmetric has tracked 19,496,717 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,564 research outputs from this source. They receive a mean Attention Score of 4.5. This one has done particularly well, scoring higher than 94% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 429,976 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 82% of its contemporaries.
We're also able to compare this research output to 113 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 98% of its contemporaries.