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Phylogenetics of a Fungal Invasion: Origins and Widespread Dispersal of White-Nose Syndrome

Overview of attention for article published in mBio, December 2017
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  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (98th percentile)
  • High Attention Score compared to outputs of the same age and source (97th percentile)

Mentioned by

news
11 news outlets
blogs
3 blogs
twitter
43 tweeters
facebook
1 Facebook page
wikipedia
1 Wikipedia page
video
1 video uploader

Citations

dimensions_citation
13 Dimensions

Readers on

mendeley
60 Mendeley
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Title
Phylogenetics of a Fungal Invasion: Origins and Widespread Dispersal of White-Nose Syndrome
Published in
mBio, December 2017
DOI 10.1128/mbio.01941-17
Pubmed ID
Authors

Kevin P. Drees, Jeffrey M. Lorch, Sebastien J. Puechmaille, Katy L. Parise, Gudrun Wibbelt, Joseph R. Hoyt, Keping Sun, Ariunbold Jargalsaikhan, Munkhnast Dalannast, Jonathan M. Palmer, Daniel L. Lindner, A. Marm Kilpatrick, Talima Pearson, Paul S. Keim, David S. Blehert, Jeffrey T. Foster

Abstract

Globalization has facilitated the worldwide movement and introduction of pathogens, but epizoological reconstructions of these invasions are often hindered by limited sampling and insufficient genetic resolution among isolates. Pseudogymnoascus destructans, a fungal pathogen causing the epizootic of white-nose syndrome in North American bats, has exhibited few genetic polymorphisms in previous studies, presenting challenges for both epizoological tracking of the spread of this fungus and for determining its evolutionary history. We used single nucleotide polymorphisms (SNPs) from whole-genome sequencing and microsatellites to construct high-resolution phylogenies of P. destructans Shallow genetic diversity and the lack of geographic structuring among North American isolates support a recent introduction followed by expansion via clonal reproduction across the epizootic zone. Moreover, the genetic relationships of isolates within North America suggest widespread mixing and long-distance movement of the fungus. Genetic diversity among isolates of P. destructans from Europe was substantially higher than in those from North America. However, genetic distance between the North American isolates and any given European isolate was similar to the distance between the individual European isolates. In contrast, the isolates we examined from Asia were highly divergent from both European and North American isolates. Although the definitive source for introduction of the North American population has not been conclusively identified, our data support the origin of the North American invasion by P. destructans from Europe rather than Asia.IMPORTANCE This phylogenetic study of the bat white-nose syndrome agent, P. destructans, uses genomics to elucidate evolutionary relationships among populations of the fungal pathogen to understand the epizoology of this biological invasion. We analyze hypervariable and abundant genetic characters (microsatellites and genomic SNPs, respectively) to reveal previously uncharacterized diversity among populations of the pathogen from North America and Eurasia. We present new evidence supporting recent introduction of the fungus to North America from a diverse Eurasian population, with limited increase in genetic variation in North America since that introduction.

Twitter Demographics

The data shown below were collected from the profiles of 43 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 60 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 60 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 17 28%
Researcher 11 18%
Student > Bachelor 7 12%
Other 7 12%
Unspecified 5 8%
Other 13 22%
Readers by discipline Count As %
Agricultural and Biological Sciences 30 50%
Biochemistry, Genetics and Molecular Biology 12 20%
Environmental Science 9 15%
Unspecified 6 10%
Veterinary Science and Veterinary Medicine 3 5%
Other 0 0%

Attention Score in Context

This research output has an Altmetric Attention Score of 121. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 January 2019.
All research outputs
#127,188
of 13,541,085 outputs
Outputs from mBio
#132
of 3,320 outputs
Outputs of similar age
#6,548
of 389,397 outputs
Outputs of similar age from mBio
#4
of 176 outputs
Altmetric has tracked 13,541,085 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,320 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 23.7. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 389,397 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 98% of its contemporaries.
We're also able to compare this research output to 176 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 97% of its contemporaries.