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No transmission of hepatitis E virus in pigs fed diets containing commercial spray-dried porcine plasma: a retrospective study of samples from several swine trials

Overview of attention for article published in Virology Journal, December 2014
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Title
No transmission of hepatitis E virus in pigs fed diets containing commercial spray-dried porcine plasma: a retrospective study of samples from several swine trials
Published in
Virology Journal, December 2014
DOI 10.1186/s12985-014-0232-x
Pubmed ID
Authors

Joan Pujols, Carmen Rodríguez, Nuria Navarro, Sonia Pina-Pedrero, Joy M Campbell, Joe Crenshaw, Javier Polo

Abstract

BackgroundHepatitis E virus (HEV) has been reported in the human population and pigs are a recognized reservoir for HEV and a possible source of HEV transmission to humans. Spray-dried porcine plasma (SDPP) is an ingredient commonly used in feed for pigs around the world. Even though processing conditions used to produce SDPP should be adequate to inactivate HEV, it was of interest to analyze commercial SDPP samples for presence of genome and antibodies (AB) against HEV and to retrospectively analyze serum samples collected from pigs used in past experiments that had been fed diets containing either 0% or 8% SDPP to detect potential transmission of HEV as determined by seroconversion.ResultsEighty-five commercial SDPP samples were analyzed by ELISA and 100% of them contained AB against HEV, while 22.4% (11 of 49 samples analyzed) were positive for HEV RNA.Frozen sera samples (n¿=¿140) collected from 70 pigs used in past experiments that had been fed diets containing either 0% or 8% commercial SDPP was analyzed by ELISA for AB against HEV. Age of pigs at sera sampling ranged from 3 to 15 weeks and feeding duration of diets ranged from approximately 4 to 9 weeks. One lot of SDPP used in one experiment was analyzed and confirmed to contain HEV RNA. Regardless of the diet fed, some sera samples collected at the beginning of an experiment contained AB titer against HEV. These sera samples were collected from weaned pigs prior to feeding of the experimental diets and the HEV titer was probably from maternal origin. However, by the end of the experiments, HEV titer was not detected or had declined by more than 50% of the initial titer concentration.ConclusionsTo our knowledge, this is the first study reporting presence of HEV AB titer and RNA in SDPP. Retrospective analysis of serum collected from pigs fed diets with SDPP revealed no indication of seroconversion to HEV. The results indicate that feeding SDPP in diets for pigs does not represent a risk of transmitting HEV, even though HEV genome may be detected in SDPP.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 34 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 3%
Portugal 1 3%
Unknown 32 94%

Demographic breakdown

Readers by professional status Count As %
Researcher 9 26%
Student > Ph. D. Student 8 24%
Student > Master 4 12%
Professor 2 6%
Librarian 1 3%
Other 3 9%
Unknown 7 21%
Readers by discipline Count As %
Agricultural and Biological Sciences 12 35%
Veterinary Science and Veterinary Medicine 5 15%
Biochemistry, Genetics and Molecular Biology 2 6%
Computer Science 2 6%
Immunology and Microbiology 2 6%
Other 2 6%
Unknown 9 26%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 02 January 2015.
All research outputs
#17,736,409
of 22,776,824 outputs
Outputs from Virology Journal
#2,245
of 3,041 outputs
Outputs of similar age
#241,711
of 353,020 outputs
Outputs of similar age from Virology Journal
#52
of 55 outputs
Altmetric has tracked 22,776,824 research outputs across all sources so far. This one is in the 19th percentile – i.e., 19% of other outputs scored the same or lower than it.
So far Altmetric has tracked 3,041 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 25.7. This one is in the 19th percentile – i.e., 19% of its peers scored the same or lower than it.
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