Title |
Highly enantioselective catalytic synthesis of chiral pyridines
|
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Published in |
Nature Communications, December 2017
|
DOI | 10.1038/s41467-017-01966-7 |
Pubmed ID | |
Authors |
Ravindra P. Jumde, Francesco Lanza, Tilde Pellegrini, Syuzanna R. Harutyunyan |
Abstract |
General methods to prepare chiral pyridine derivatives are greatly sought after due to their significance in medicinal chemistry. Here, we report highly enantioselective catalytic transformations of poorly reactive β-substituted alkenyl pyridines to access a wide range of alkylated chiral pyridines. The simple methodology involves reactivity enhancement via Lewis acid (LA) activation, the use of readily available and highly reactive Grignard reagents, and a copper-chiral diphosphine ligand catalyst. Apart from allowing the introduction of different linear, branched, cyclic, and functionalised alkyl chains at the β-position of alkenyl pyridines, the catalytic system also shows high functional group tolerance. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Unknown | 104 | 100% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Bachelor | 34 | 33% |
Student > Master | 8 | 8% |
Student > Ph. D. Student | 6 | 6% |
Researcher | 5 | 5% |
Student > Doctoral Student | 1 | <1% |
Other | 2 | 2% |
Unknown | 48 | 46% |
Readers by discipline | Count | As % |
---|---|---|
Chemistry | 28 | 27% |
Biochemistry, Genetics and Molecular Biology | 18 | 17% |
Materials Science | 2 | 2% |
Psychology | 1 | <1% |
Chemical Engineering | 1 | <1% |
Other | 2 | 2% |
Unknown | 52 | 50% |