Title |
Protein fibrils in nature can enhance amyloid protein A amyloidosis in mice: Cross-seeding as a disease mechanism
|
---|---|
Published in |
Proceedings of the National Academy of Sciences of the United States of America, April 2005
|
DOI | 10.1073/pnas.0501814102 |
Pubmed ID | |
Authors |
Katarzyna Lundmark, Gunilla T. Westermark, Arne Olsén, Per Westermark |
Abstract |
Secondary, or amyloid protein A (AA), amyloidosis is a complication of chronic inflammatory diseases, both infectious and noninfectious. AA constitutes the insoluble fibrils, which are deposited in different organs, and is a major N-terminal part of the acute phase protein serum AA. It is not known why only some patients with chronic inflammation develop AA amyloidosis. Nucleation is a widely accepted mechanism in amyloidogenesis. Preformed amyloid-like fibrils act as nuclei in amyloid fibril formation in vitro, and AA amyloid fibrils and synthetic amyloid-like fibrils also may serve as seed for fibril formation in vivo. In addition to amyloid fibrils, there is a variety of similar nonmammalian protein fibrils with beta-pleated structure in nature. We studied three such naturally occurring protein fibrils: silk from Bombyx mori, Sup35 from Saccharomyces cerevisiae, and curli from Escherichia coli. Our results show that these protein fibrils exert amyloid-accelerating properties in the murine experimental AA amyloidosis, suggesting that such environment factors may be important risk factors in amyloidogenesis. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 2 | <1% |
United Kingdom | 1 | <1% |
Chile | 1 | <1% |
South Africa | 1 | <1% |
Unknown | 202 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Ph. D. Student | 42 | 20% |
Researcher | 37 | 18% |
Student > Bachelor | 26 | 13% |
Student > Master | 18 | 9% |
Student > Doctoral Student | 13 | 6% |
Other | 33 | 16% |
Unknown | 38 | 18% |
Readers by discipline | Count | As % |
---|---|---|
Agricultural and Biological Sciences | 54 | 26% |
Biochemistry, Genetics and Molecular Biology | 41 | 20% |
Medicine and Dentistry | 15 | 7% |
Chemistry | 15 | 7% |
Neuroscience | 14 | 7% |
Other | 25 | 12% |
Unknown | 43 | 21% |