Regioselective synthesis of 2-(bromomethyl)-5-aryl-thiophene derivatives viapalladium (0) catalyzed suzuki cross-coupling reactions: as antithrombotic and haemolytically active molecules

Regioselective synthesis of 2-(bromomethyl)-5-aryl-thiophene derivatives viapalladium (0) catalyzed suzuki cross-coupling reactions: as antithrombotic and haemolytically active molecules

BMC Chemistry, December 2014

25685184

Komal Rizwan, Muhammad Zubair, Nasir Rasool, Shaukat Ali, Ameer Fawad Zahoor, Usman Ali Rana, Salah Ud-Din Khan, Muhammad Shahid, Muhammad Zia-Ul-Haq, Hawa ZE Jaafar

It is seen that the regioselective functionalizations of halogenated heterocycles play an important role in the synthesis of several types of organic compounds. In this domain, the Suzuki-Miyaura reaction has emerged as a convenient way to build carbon-carbon bonds in synthesizing organic compounds. Some of the most important applications of these reactions can be seen in the synthesis of natural products, and in designing targeted pharmaceutical compounds. Herein, we present the regioselective synthesis of the novel series of 2-(bromomethyl)-5-aryl-thiophenes 3a-i, via Suzuki cross-coupling reactions of various aryl boronic acids with 2-bromo-5-(bromomethyl)thiophene (2).