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Charge-driven dynamics of nascent-chain movement through the SecYEG translocon

Overview of attention for article published in Nature Structural & Molecular Biology, January 2015
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  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (81st percentile)

Mentioned by

news
1 news outlet

Citations

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69 Dimensions

Readers on

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84 Mendeley
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Title
Charge-driven dynamics of nascent-chain movement through the SecYEG translocon
Published in
Nature Structural & Molecular Biology, January 2015
DOI 10.1038/nsmb.2940
Pubmed ID
Authors

Nurzian Ismail, Rickard Hedman, Martin Lindén, Gunnar von Heijne

Abstract

On average, every fifth residue in secretory proteins carries either a positive or a negative charge. In a bacterium such as Escherichia coli, charged residues are exposed to an electric field as they transit through the inner membrane, and this should generate a fluctuating electric force on a translocating nascent chain. Here, we have used translational arrest peptides as in vivo force sensors to measure this electric force during cotranslational chain translocation through the SecYEG translocon. We find that charged residues experience a biphasic electric force as they move across the membrane, including an early component with a maximum when they are 47-49 residues away from the ribosomal P site, followed by a more slowly varying component. The early component is generated by the transmembrane electric potential, whereas the second may reflect interactions between charged residues and the periplasmic membrane surface.

Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 84 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Netherlands 2 2%
United Kingdom 1 1%
India 1 1%
Switzerland 1 1%
Unknown 79 94%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 25 30%
Researcher 10 12%
Student > Master 10 12%
Student > Doctoral Student 7 8%
Student > Bachelor 5 6%
Other 12 14%
Unknown 15 18%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 39 46%
Agricultural and Biological Sciences 23 27%
Chemistry 3 4%
Physics and Astronomy 1 1%
Energy 1 1%
Other 1 1%
Unknown 16 19%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 January 2015.
All research outputs
#4,841,279
of 25,394,764 outputs
Outputs from Nature Structural & Molecular Biology
#1,674
of 4,187 outputs
Outputs of similar age
#62,215
of 359,008 outputs
Outputs of similar age from Nature Structural & Molecular Biology
#35
of 49 outputs
Altmetric has tracked 25,394,764 research outputs across all sources so far. Compared to these this one has done well and is in the 79th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 4,187 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 15.5. This one has gotten more attention than average, scoring higher than 57% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 359,008 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 81% of its contemporaries.
We're also able to compare this research output to 49 others from the same source and published within six weeks on either side of this one. This one is in the 26th percentile – i.e., 26% of its contemporaries scored the same or lower than it.