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Charge-driven dynamics of nascent-chain movement through the SecYEG translocon

Overview of attention for article published in Nature Structural & Molecular Biology, January 2015
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (82nd percentile)

Mentioned by

news
1 news outlet

Citations

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31 Dimensions

Readers on

mendeley
57 Mendeley
Title
Charge-driven dynamics of nascent-chain movement through the SecYEG translocon
Published in
Nature Structural & Molecular Biology, January 2015
DOI 10.1038/nsmb.2940
Pubmed ID
Authors

Nurzian Ismail, Rickard Hedman, Martin Lindén, Gunnar von Heijne

Abstract

On average, every fifth residue in secretory proteins carries either a positive or a negative charge. In a bacterium such as Escherichia coli, charged residues are exposed to an electric field as they transit through the inner membrane, and this should generate a fluctuating electric force on a translocating nascent chain. Here, we have used translational arrest peptides as in vivo force sensors to measure this electric force during cotranslational chain translocation through the SecYEG translocon. We find that charged residues experience a biphasic electric force as they move across the membrane, including an early component with a maximum when they are 47-49 residues away from the ribosomal P site, followed by a more slowly varying component. The early component is generated by the transmembrane electric potential, whereas the second may reflect interactions between charged residues and the periplasmic membrane surface.

Mendeley readers

The data shown below were compiled from readership statistics for 57 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Netherlands 2 4%
India 1 2%
United Kingdom 1 2%
Switzerland 1 2%
Unknown 52 91%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 19 33%
Researcher 8 14%
Student > Master 7 12%
Student > Bachelor 5 9%
Student > Doctoral Student 5 9%
Other 8 14%
Unknown 5 9%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 25 44%
Agricultural and Biological Sciences 21 37%
Chemistry 4 7%
Physics and Astronomy 1 2%
Materials Science 1 2%
Other 0 0%
Unknown 5 9%

Attention Score in Context

This research output has an Altmetric Attention Score of 7. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 05 January 2015.
All research outputs
#612,007
of 4,697,597 outputs
Outputs from Nature Structural & Molecular Biology
#304
of 1,664 outputs
Outputs of similar age
#26,450
of 156,130 outputs
Outputs of similar age from Nature Structural & Molecular Biology
#33
of 48 outputs
Altmetric has tracked 4,697,597 research outputs across all sources so far. Compared to these this one has done well and is in the 86th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 1,664 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.2. This one has done well, scoring higher than 81% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 156,130 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 82% of its contemporaries.
We're also able to compare this research output to 48 others from the same source and published within six weeks on either side of this one. This one is in the 29th percentile – i.e., 29% of its contemporaries scored the same or lower than it.