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Correlation between distribution of muscle weakness, electrophysiological findings and CTG expansion in myotonic dystrophy

Overview of attention for article published in Journal of Clinical Neuroscience, July 2014
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Title
Correlation between distribution of muscle weakness, electrophysiological findings and CTG expansion in myotonic dystrophy
Published in
Journal of Clinical Neuroscience, July 2014
DOI 10.1016/j.jocn.2013.09.016
Pubmed ID
Authors

Roya Khoshbakht, Akbar Soltanzadeh, Babak Zamani, Siyamak Abdi, Kourosh Gharagozli, Kimia Kahrizi, Rahem Khoshbakht, Shahriar Nafissi

Abstract

Myotonic dystrophy type 1 (DM-1) is a multi-system disorder affecting the muscles, brain, cardiovascular system, endocrine system, eyes and skin. Diagnosis is made by clinical, electrodiagnostic and genetic studies. This study aimed to determine the correlation between CTG expansion and distribution of muscle weakness and clinical and electrophysiological findings. Genetically confirmed DM-1 patients presenting to Shariati Hospital between 2005 and 2011 were included in this study. Clinical, electrodiagnostic and genetic testing was performed and the correlation between CTG expansion and distribution of muscle weakness and clinical and electromyographic findings was studied. Thirty-three genetically confirmed DM-1 patients were enrolled. Myotonia, bifacial weakness and distal upper limb weakness were seen in all patients. Diabetes mellitus was found in one patient (3%), cardiac disturbance in eight (24.2%), cataracts in eight (24.2%), hypogonadism in five (15.2%), frontal baldness in 13 (39.4%), temporalis wasting in 14 (42.4%), temporomandibular joint disorder in seven (21.2%) and mental retardation in eight (24.2%). The mean number of CTG repeats, measured by Southern blot, was 8780 (range 500-15,833). A negative correlation was found between CTG expansion and age of onset. Temporalis wasting and mental retardation were positively correlated with CTG expansion. No relationship was found between weakness distribution, electromyographic findings, other systemic features and CTG expansion. In this study of DM-1 in Iran, we found a correlation between CTG expansion and age of onset, temporalis wasting and mental disability. No correlation between CTG expansion and electrodiagnostic and other clinical findings were detected.

Twitter Demographics

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Mendeley readers

The data shown below were compiled from readership statistics for 45 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United Kingdom 1 2%
United States 1 2%
Unknown 43 96%

Demographic breakdown

Readers by professional status Count As %
Student > Master 8 18%
Student > Doctoral Student 6 13%
Student > Ph. D. Student 5 11%
Researcher 5 11%
Professor > Associate Professor 4 9%
Other 13 29%
Unknown 4 9%
Readers by discipline Count As %
Medicine and Dentistry 21 47%
Psychology 3 7%
Sports and Recreations 3 7%
Social Sciences 2 4%
Agricultural and Biological Sciences 2 4%
Other 8 18%
Unknown 6 13%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 07 January 2015.
All research outputs
#2,419,651
of 4,707,063 outputs
Outputs from Journal of Clinical Neuroscience
#197
of 529 outputs
Outputs of similar age
#79,900
of 156,671 outputs
Outputs of similar age from Journal of Clinical Neuroscience
#5
of 15 outputs
Altmetric has tracked 4,707,063 research outputs across all sources so far. This one is in the 35th percentile – i.e., 35% of other outputs scored the same or lower than it.
So far Altmetric has tracked 529 research outputs from this source. They receive a mean Attention Score of 2.1. This one is in the 45th percentile – i.e., 45% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 156,671 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 37th percentile – i.e., 37% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 15 others from the same source and published within six weeks on either side of this one. This one is in the 33rd percentile – i.e., 33% of its contemporaries scored the same or lower than it.