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Polyspecific antibodies without persisting antigen in multiple sclerosis, neurolupus and Guillain-Barré syndrome: immune network connectivity in chronic diseases

Overview of attention for article published in Arquivos de Neuro-Psiquiatria, August 2017
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About this Attention Score

  • Above-average Attention Score compared to outputs of the same age (64th percentile)

Mentioned by

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1 policy source
twitter
1 tweeter

Citations

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11 Dimensions

Readers on

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22 Mendeley
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Title
Polyspecific antibodies without persisting antigen in multiple sclerosis, neurolupus and Guillain-Barré syndrome: immune network connectivity in chronic diseases
Published in
Arquivos de Neuro-Psiquiatria, August 2017
DOI 10.1590/0004-282x20170081
Pubmed ID
Authors

Hansotto Reiber

Abstract

The polyspecific antibody synthesis in multiple sclerosis (MS) gained diagnostic relevance with the frequent combination of measles-, rubella- and varicella zoster antibodies (MRZ-antibody reaction) but their pathophysiological role remains unknown. This review connects the data for intrathecal polyspecific antibody synthesis in MS and neurolupus with observations in the blood of patients with Guillain-Barré syndrome (GBS). Simultaneously increased antibody and autoantibody titers in GBS blood samples indicate that the polyspecific antibodies are based on a general property of an immune network, supported by the deterministic day-to-day concentration variation of antibodies in normal blood. Strongly correlated measles- and rubella- antibody variations point to a particular connectivity between the MRZ antibodies. The immune network, which provides serological memory in the absence of an antigen, implements the continuous change of the MRZ pattern in blood, not followed by the earlier immigrated B cells without corresponding connectivity in the brain. This may explain the different antibody patterns in cerebrospinal fluid, aqueous humor and blood of the individual MS patient. A complexity approach must implement a different view on causation in chronic diseases and causal therapies.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 22 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 22 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 3 14%
Professor > Associate Professor 2 9%
Student > Ph. D. Student 2 9%
Professor 2 9%
Librarian 1 5%
Other 5 23%
Unknown 7 32%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 4 18%
Medicine and Dentistry 3 14%
Immunology and Microbiology 3 14%
Neuroscience 3 14%
Business, Management and Accounting 1 5%
Other 1 5%
Unknown 7 32%

Attention Score in Context

This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 25 July 2019.
All research outputs
#5,421,901
of 17,367,552 outputs
Outputs from Arquivos de Neuro-Psiquiatria
#125
of 731 outputs
Outputs of similar age
#144,591
of 417,692 outputs
Outputs of similar age from Arquivos de Neuro-Psiquiatria
#1
of 1 outputs
Altmetric has tracked 17,367,552 research outputs across all sources so far. This one has received more attention than most of these and is in the 68th percentile.
So far Altmetric has tracked 731 research outputs from this source. They receive a mean Attention Score of 3.0. This one has done well, scoring higher than 81% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 417,692 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 64% of its contemporaries.
We're also able to compare this research output to 1 others from the same source and published within six weeks on either side of this one. This one has scored higher than all of them