↓ Skip to main content

Human gut Bacteroidetes can utilize yeast mannan through a selfish mechanism

Overview of attention for article published in Nature, January 2015
Altmetric Badge

About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (81st percentile)

Mentioned by

news
14 news outlets
blogs
12 blogs
twitter
101 tweeters
patent
2 patents
facebook
8 Facebook pages
wikipedia
2 Wikipedia pages

Citations

dimensions_citation
140 Dimensions

Readers on

mendeley
351 Mendeley
citeulike
3 CiteULike
Title
Human gut Bacteroidetes can utilize yeast mannan through a selfish mechanism
Published in
Nature, January 2015
DOI 10.1038/nature13995
Pubmed ID
Authors

Fiona Cuskin, Elisabeth C. Lowe, Max J. Temple, Yanping Zhu, Elizabeth A. Cameron, Nicholas A. Pudlo, Nathan T. Porter, Karthik Urs, Andrew J. Thompson, Alan Cartmell, Artur Rogowski, Brian S. Hamilton, Rui Chen, Thomas J. Tolbert, Kathleen Piens, Debby Bracke, Wouter Vervecken, Zalihe Hakki, Gaetano Speciale, Jose L. Munōz-Munōz, Andrew Day, Maria J. Peña, Richard McLean, Michael D. Suits, Alisdair B. Boraston, Todd Atherly, Cherie J. Ziemer, Spencer J. Williams, Gideon J. Davies, D. Wade Abbott, Eric C. Martens, Harry J. Gilbert

Abstract

Yeasts, which have been a component of the human diet for at least 7,000 years, possess an elaborate cell wall α-mannan. The influence of yeast mannan on the ecology of the human microbiota is unknown. Here we show that yeast α-mannan is a viable food source for the Gram-negative bacterium Bacteroides thetaiotaomicron, a dominant member of the microbiota. Detailed biochemical analysis and targeted gene disruption studies support a model whereby limited cleavage of α-mannan on the surface generates large oligosaccharides that are subsequently depolymerized to mannose by the action of periplasmic enzymes. Co-culturing studies showed that metabolism of yeast mannan by B. thetaiotaomicron presents a 'selfish' model for the catabolism of this difficult to breakdown polysaccharide. Genomic comparison with B. thetaiotaomicron in conjunction with cell culture studies show that a cohort of highly successful members of the microbiota has evolved to consume sterically-restricted yeast glycans, an adaptation that may reflect the incorporation of eukaryotic microorganisms into the human diet.

Twitter Demographics

The data shown below were collected from the profiles of 101 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 351 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 10 3%
Canada 4 1%
United Kingdom 4 1%
Germany 2 <1%
France 2 <1%
Spain 2 <1%
India 1 <1%
Brazil 1 <1%
Belgium 1 <1%
Other 6 2%
Unknown 318 91%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 101 29%
Researcher 91 26%
Student > Master 34 10%
Student > Bachelor 25 7%
Student > Doctoral Student 19 5%
Other 81 23%
Readers by discipline Count As %
Agricultural and Biological Sciences 180 51%
Biochemistry, Genetics and Molecular Biology 62 18%
Unspecified 29 8%
Immunology and Microbiology 21 6%
Medicine and Dentistry 15 4%
Other 44 13%

Attention Score in Context

This research output has an Altmetric Attention Score of 246. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 24 August 2018.
All research outputs
#47,353
of 12,980,093 outputs
Outputs from Nature
#5,234
of 68,110 outputs
Outputs of similar age
#1,110
of 290,833 outputs
Outputs of similar age from Nature
#150
of 831 outputs
Altmetric has tracked 12,980,093 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 68,110 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 74.1. This one has done particularly well, scoring higher than 92% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 290,833 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 831 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 81% of its contemporaries.