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Human gut Bacteroidetes can utilize yeast mannan through a selfish mechanism

Overview of attention for article published in Nature, January 2015
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About this Attention Score

  • In the top 5% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (99th percentile)
  • High Attention Score compared to outputs of the same age and source (82nd percentile)

Mentioned by

news
14 news outlets
blogs
13 blogs
twitter
98 tweeters
patent
5 patents
facebook
8 Facebook pages
wikipedia
2 Wikipedia pages

Citations

dimensions_citation
283 Dimensions

Readers on

mendeley
468 Mendeley
citeulike
3 CiteULike
Title
Human gut Bacteroidetes can utilize yeast mannan through a selfish mechanism
Published in
Nature, January 2015
DOI 10.1038/nature13995
Pubmed ID
Authors

Fiona Cuskin, Elisabeth C. Lowe, Max J. Temple, Yanping Zhu, Elizabeth A. Cameron, Nicholas A. Pudlo, Nathan T. Porter, Karthik Urs, Andrew J. Thompson, Alan Cartmell, Artur Rogowski, Brian S. Hamilton, Rui Chen, Thomas J. Tolbert, Kathleen Piens, Debby Bracke, Wouter Vervecken, Zalihe Hakki, Gaetano Speciale, Jose L. Munōz-Munōz, Andrew Day, Maria J. Peña, Richard McLean, Michael D. Suits, Alisdair B. Boraston, Todd Atherly, Cherie J. Ziemer, Spencer J. Williams, Gideon J. Davies, D. Wade Abbott, Eric C. Martens, Harry J. Gilbert

Abstract

Yeasts, which have been a component of the human diet for at least 7,000 years, possess an elaborate cell wall α-mannan. The influence of yeast mannan on the ecology of the human microbiota is unknown. Here we show that yeast α-mannan is a viable food source for the Gram-negative bacterium Bacteroides thetaiotaomicron, a dominant member of the microbiota. Detailed biochemical analysis and targeted gene disruption studies support a model whereby limited cleavage of α-mannan on the surface generates large oligosaccharides that are subsequently depolymerized to mannose by the action of periplasmic enzymes. Co-culturing studies showed that metabolism of yeast mannan by B. thetaiotaomicron presents a 'selfish' model for the catabolism of this difficult to breakdown polysaccharide. Genomic comparison with B. thetaiotaomicron in conjunction with cell culture studies show that a cohort of highly successful members of the microbiota has evolved to consume sterically-restricted yeast glycans, an adaptation that may reflect the incorporation of eukaryotic microorganisms into the human diet.

Twitter Demographics

The data shown below were collected from the profiles of 98 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 468 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 10 2%
Canada 4 <1%
United Kingdom 4 <1%
Germany 2 <1%
France 2 <1%
Spain 2 <1%
China 1 <1%
Belgium 1 <1%
India 1 <1%
Other 4 <1%
Unknown 437 93%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 121 26%
Researcher 112 24%
Student > Master 48 10%
Student > Bachelor 38 8%
Student > Doctoral Student 25 5%
Other 77 16%
Unknown 47 10%
Readers by discipline Count As %
Agricultural and Biological Sciences 188 40%
Biochemistry, Genetics and Molecular Biology 97 21%
Immunology and Microbiology 33 7%
Chemistry 21 4%
Medicine and Dentistry 20 4%
Other 43 9%
Unknown 66 14%

Attention Score in Context

This research output has an Altmetric Attention Score of 252. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 April 2021.
All research outputs
#87,826
of 19,152,115 outputs
Outputs from Nature
#7,409
of 83,378 outputs
Outputs of similar age
#1,316
of 327,150 outputs
Outputs of similar age from Nature
#142
of 815 outputs
Altmetric has tracked 19,152,115 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 83,378 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 93.7. This one has done particularly well, scoring higher than 91% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 327,150 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 815 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 82% of its contemporaries.