| Title |
Human gut Bacteroidetes can utilize yeast mannan through a selfish mechanism
|
|---|---|
| Published in |
Nature, January 2015
|
| DOI | 10.1038/nature13995 |
| Pubmed ID | |
| Authors |
Fiona Cuskin, Elisabeth C. Lowe, Max J. Temple, Yanping Zhu, Elizabeth A. Cameron, Nicholas A. Pudlo, Nathan T. Porter, Karthik Urs, Andrew J. Thompson, Alan Cartmell, Artur Rogowski, Brian S. Hamilton, Rui Chen, Thomas J. Tolbert, Kathleen Piens, Debby Bracke, Wouter Vervecken, Zalihe Hakki, Gaetano Speciale, Jose L. Munōz-Munōz, Andrew Day, Maria J. Peña, Richard McLean, Michael D. Suits, Alisdair B. Boraston, Todd Atherly, Cherie J. Ziemer, Spencer J. Williams, Gideon J. Davies, D. Wade Abbott, Eric C. Martens, Harry J. Gilbert |
| Abstract |
Yeasts, which have been a component of the human diet for at least 7,000 years, possess an elaborate cell wall α-mannan. The influence of yeast mannan on the ecology of the human microbiota is unknown. Here we show that yeast α-mannan is a viable food source for the Gram-negative bacterium Bacteroides thetaiotaomicron, a dominant member of the microbiota. Detailed biochemical analysis and targeted gene disruption studies support a model whereby limited cleavage of α-mannan on the surface generates large oligosaccharides that are subsequently depolymerized to mannose by the action of periplasmic enzymes. Co-culturing studies showed that metabolism of yeast mannan by B. thetaiotaomicron presents a 'selfish' model for the catabolism of this difficult to breakdown polysaccharide. Genomic comparison with B. thetaiotaomicron in conjunction with cell culture studies show that a cohort of highly successful members of the microbiota has evolved to consume sterically-restricted yeast glycans, an adaptation that may reflect the incorporation of eukaryotic microorganisms into the human diet. |
X Demographics
The data shown below were collected from the profiles of 91 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 22 | 24% |
| United Kingdom | 13 | 14% |
| Canada | 3 | 3% |
| Japan | 3 | 3% |
| Mexico | 2 | 2% |
| Finland | 1 | 1% |
| Australia | 1 | 1% |
| Norway | 1 | 1% |
| South Africa | 1 | 1% |
| Other | 2 | 2% |
| Unknown | 42 | 46% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 57 | 63% |
| Scientists | 27 | 30% |
| Practitioners (doctors, other healthcare professionals) | 4 | 4% |
| Science communicators (journalists, bloggers, editors) | 3 | 3% |
Mendeley readers
The data shown below were compiled from readership statistics for 570 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 10 | 2% |
| United Kingdom | 4 | <1% |
| Canada | 4 | <1% |
| France | 2 | <1% |
| Germany | 2 | <1% |
| Spain | 2 | <1% |
| Argentina | 1 | <1% |
| Belgium | 1 | <1% |
| Korea, Republic of | 1 | <1% |
| Other | 3 | <1% |
| Unknown | 540 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 136 | 24% |
| Researcher | 123 | 22% |
| Student > Master | 57 | 10% |
| Student > Bachelor | 43 | 8% |
| Student > Doctoral Student | 34 | 6% |
| Other | 88 | 15% |
| Unknown | 89 | 16% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 208 | 36% |
| Biochemistry, Genetics and Molecular Biology | 115 | 20% |
| Immunology and Microbiology | 37 | 6% |
| Chemistry | 25 | 4% |
| Medicine and Dentistry | 19 | 3% |
| Other | 54 | 9% |
| Unknown | 112 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 263. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 13 June 2023.
All research outputs
#140,431
of 25,654,806 outputs
Outputs from Nature
#9,051
of 98,462 outputs
Outputs of similar age
#1,452
of 360,488 outputs
Outputs of similar age from Nature
#142
of 895 outputs
Altmetric has tracked 25,654,806 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 98,462 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 102.6. This one has done particularly well, scoring higher than 90% of its peers.
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We're also able to compare this research output to 895 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 84% of its contemporaries.