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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Efficacy and pharmacokinetic evaluation of a novel anti-malarial compound (NP046) in a mouse model
|
|---|---|
| Published in |
Malaria Journal, January 2015
|
| DOI | 10.1186/1475-2875-14-8 |
| Pubmed ID | |
| Authors |
Efrem T Abay, Jan H van der Westuizen, Kenneth J Swart, Liezl Gibhard, Nina Lawrence, Ntokozo Dambuza, Anke Wilhelm, Kendrekar Pravin, Lubbe Wiesner |
| Abstract |
Even though malaria is a completely preventable and treatable disease, it remains a threat to human life and a burden to the global economy due to the emergence of multiple-drug resistant malaria parasites. According to the World Malaria Report 2013, in 2012 there were an estimated 207 million malaria cases and 627,000 deaths. Thus, the discovery and development of new, effective anti-malarial drugs are required. To achieve this goal, the Department of Chemistry at the University of the Free State has synthesized a number of novel amino-alkylated chalcones and analogues, which showed in vitro anti-malarial activity against both chloroquine-sensitive and chloroquine-resistant Plasmodium falciparum strains. The lead compound (NP046) was selected for a comprehensive pharmacokinetic (PK) and in vivo efficacy evaluation in a mouse model. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 36 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 1 | 3% |
| Unknown | 35 | 97% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 9 | 25% |
| Researcher | 4 | 11% |
| Student > Bachelor | 4 | 11% |
| Other | 3 | 8% |
| Student > Postgraduate | 3 | 8% |
| Other | 8 | 22% |
| Unknown | 5 | 14% |
| Readers by discipline | Count | As % |
|---|---|---|
| Medicine and Dentistry | 12 | 33% |
| Agricultural and Biological Sciences | 8 | 22% |
| Pharmacology, Toxicology and Pharmaceutical Science | 4 | 11% |
| Chemistry | 3 | 8% |
| Computer Science | 1 | 3% |
| Other | 3 | 8% |
| Unknown | 5 | 14% |
Attention Score in Context
This research output has an Altmetric Attention Score of 4. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 10 January 2019.
All research outputs
#6,410,648
of 22,776,824 outputs
Outputs from Malaria Journal
#1,852
of 5,557 outputs
Outputs of similar age
#87,910
of 352,333 outputs
Outputs of similar age from Malaria Journal
#39
of 125 outputs
Altmetric has tracked 22,776,824 research outputs across all sources so far. This one has received more attention than most of these and is in the 70th percentile.
So far Altmetric has tracked 5,557 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.8. This one has gotten more attention than average, scoring higher than 65% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 352,333 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 73% of its contemporaries.
We're also able to compare this research output to 125 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 68% of its contemporaries.