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Immunotoxicity of silicon dioxide nanoparticles with different sizes and electrostatic charge

Overview of attention for article published in International Journal of Nanomedicine, December 2014
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3 tweeters

Citations

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38 Dimensions

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58 Mendeley
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Title
Immunotoxicity of silicon dioxide nanoparticles with different sizes and electrostatic charge
Published in
International Journal of Nanomedicine, December 2014
DOI 10.2147/ijn.s57934
Pubmed ID
Authors

Soo-Ki Kim, Jae-Heon Kim, Cheol-Su Kim, Rosa Mistica Ignacio, Dong-Heui Kim, Ma. Easter Joy Sajo, Eun-Ho Meang, Xu-Feng Qi, Seong-Eun Park, Yu-Ri Kim, Myeong-Kon Kim, Kyu-Jae Lee, Seong Soo A. An

Abstract

Silicon dioxide (SiO2) nanoparticles (NPs) have been widely used in the biomedical field, such as in drug delivery and gene therapy. However, little is known about the biological effects and potential hazards of SiO2. Herein, the colloidal SiO2 NPs with two different sizes (20 nm and 100 nm) and different charges (L-arginine modified: SiO2 (EN20[R]), SiO2 (EN100[R]); and negative: SiO2 (EN20[-]), SiO2 (EN100[-]) were orally administered (750 mg/kg/day) in female C57BL/6 mice for 14 days. Assessments of immunotoxicity include hematology profiling, reactive oxygen species generation and their antioxidant effect, stimulation assays for B- and T-lymphocytes, the activity of natural killer (NK) cells, and cytokine profiling. In vitro toxicity was also investigated in the RAW 264.7 cell line. When the cellularity of mouse spleen was evaluated, there was an overall decrease in the proliferation of B- and T-cells for all the groups fed with SiO2 NPs. Specifically, the SiO2 (EN20(-)) NPs showed the most pronounced reduction. In addition, the nitric oxide production and NK cell activity in SiO2 NP-fed mice were significantly suppressed. Moreover, there was a decrease in the serum concentration of inflammatory cytokines such as interleukin (IL)-1β, IL-12 (p70), IL-6, tumor necrosis factor-α, and interferon-γ. To elucidate the cytotoxicity mechanism of SiO2 in vivo, an in vitro study using the RAW 264.7 cell line was performed. Both the size and charge of SiO2 using murine macrophage RAW 264.7 cells decreased cell viability dose-dependently. Collectively, our data indicate that different sized and charged SiO2 NPs would cause differential immunotoxicity. Interestingly, the small-sized and negatively charged SiO2 NPs showed the most potent in vivo immunotoxicity by way of suppressing the proliferation of lymphocytes, depressing the killing activity of NK cells, and decreasing proinflammatory cytokine production, thus leading to immunosuppression.

Twitter Demographics

The data shown below were collected from the profiles of 3 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 58 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 2 3%
Unknown 56 97%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 15 26%
Researcher 10 17%
Student > Master 8 14%
Student > Doctoral Student 5 9%
Student > Bachelor 4 7%
Other 8 14%
Unknown 8 14%
Readers by discipline Count As %
Agricultural and Biological Sciences 12 21%
Medicine and Dentistry 7 12%
Chemistry 6 10%
Pharmacology, Toxicology and Pharmaceutical Science 5 9%
Biochemistry, Genetics and Molecular Biology 4 7%
Other 13 22%
Unknown 11 19%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 29 February 2016.
All research outputs
#7,498,534
of 12,438,331 outputs
Outputs from International Journal of Nanomedicine
#1,088
of 2,456 outputs
Outputs of similar age
#132,749
of 278,347 outputs
Outputs of similar age from International Journal of Nanomedicine
#16
of 49 outputs
Altmetric has tracked 12,438,331 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,456 research outputs from this source. They receive a mean Attention Score of 3.0. This one is in the 41st percentile – i.e., 41% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 278,347 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 48th percentile – i.e., 48% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 49 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 59% of its contemporaries.