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An association study of Taq1A ANKK1 and C957T and − 141C DRD2 polymorphisms in adults with internet gaming disorder: a pilot study

Overview of attention for article published in Annals of General Psychiatry, December 2017
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Title
An association study of Taq1A ANKK1 and C957T and − 141C DRD2 polymorphisms in adults with internet gaming disorder: a pilot study
Published in
Annals of General Psychiatry, December 2017
DOI 10.1186/s12991-017-0168-9
Pubmed ID
Authors

Soo-Hyun Paik, Mi Ran Choi, Su Min Kwak, Sol Hee Bang, Ji-Won Chun, Jin-Young Kim, Jihye Choi, Hyun Cho, Jo-Eun Jeong, Dai-Jin Kim

Abstract

Though Internet gaming disorder (IGD) is considered to share similar genetic vulnerability with substance addictions, little has been explored about the role of the genetic variants on IGD. This pilot study was designed to investigate the association of the Taq1A polymorphism of the ankyrin repeat and kinase domain containing 1 (ANKK1) gene and C957T and - 141C of the dopamine D2 receptor (DRD2) with IGD and their role on the personality and temperament traits in IGD among adult population. Sixty-three subjects with IGD and 87 control subjects who regularly played Internet games were recruited. Self-administered questionnaires on self-control, dysfunctional impulsivity, and temperament and character domains were done. The Taq1A ANKK1 and the C957T and - 141C ins/del from the DRD2 genes were genotyped using the specific TaqMan PCR assay. The distributions of allele and genotype frequencies were not significantly different between the IGD and control groups in both genders. In male, excessive gaming and use of gaming to escape from a negative feeling were associated with the del- genotype of the - 141C. Among IGD, the del+ genotype was associated with higher novelty seeking. Logistic regression showed no predictive value of these polymorphisms for IGD when using age and gender as covariates. Though no direct association of the Taq1A ANKK1 and C957T DRD2 variants with IGD were observed, the - 141C polymorphism may play a role in IGD via mediating symptoms or temperament traits.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 43 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 43 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 7 16%
Student > Postgraduate 5 12%
Student > Master 5 12%
Student > Bachelor 5 12%
Professor 2 5%
Other 10 23%
Unknown 9 21%
Readers by discipline Count As %
Psychology 12 28%
Medicine and Dentistry 8 19%
Neuroscience 4 9%
Biochemistry, Genetics and Molecular Biology 3 7%
Agricultural and Biological Sciences 2 5%
Other 6 14%
Unknown 8 19%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 December 2017.
All research outputs
#18,578,649
of 23,011,300 outputs
Outputs from Annals of General Psychiatry
#366
of 514 outputs
Outputs of similar age
#327,466
of 439,775 outputs
Outputs of similar age from Annals of General Psychiatry
#8
of 9 outputs
Altmetric has tracked 23,011,300 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 514 research outputs from this source. They typically receive more attention than average, with a mean Attention Score of 8.2. This one is in the 17th percentile – i.e., 17% of its peers scored the same or lower than it.
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