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Catechol-O-methyltransferase (COMT) polymorphisms modulate working memory in individuals with schizophrenia and healthy controls

Overview of attention for article published in Brazilian Journal of Psychiatry, December 2017
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Title
Catechol-O-methyltransferase (COMT) polymorphisms modulate working memory in individuals with schizophrenia and healthy controls
Published in
Brazilian Journal of Psychiatry, December 2017
DOI 10.1590/1516-4446-2016-1987
Pubmed ID
Authors

Camila T. Matsuzaka, Denise Christofolini, Vanessa K. Ota, Ary Gadelha, Arthur A. Berberian, Cristiano Noto, Diego R. Mazzotti, Leticia M. Spindola, Patricia N. Moretti, Marilia A.C. Smith, Maria I. Melaragno, Sintia I. Belangero, Rodrigo A. Bressan

Abstract

Cognitive impairment is a core feature of schizophrenia, related to dopaminergic dysfunction in the prefrontal cortex (PFC). It is hypothesized that functional single nucleotide polymorphism (SNP) rs4680 of the catechol-O-methyltransferase (COMT) gene could mediate the relationship between cognition and dopamine activity in the PFC. Other COMT SNPs could also play a role. We evaluated the role of three COMT SNPs (rs737865, rs165599, and rs4680) in schizophrenia and their impact on three working memory tasks. For genetic association analyses, 212 individuals with schizophrenia and 257 healthy controls (HCs) were selected. The Visual Working Memory (VWM) Task, Keep Track Task, and Letter Memory Task were administered to 133 schizophrenics and 93 HCs. We found a significant association of rs737865, with the GG genotype exerting a protective effect and the GA haplotype (rs4680/rs165599) exerting a risk effect for schizophrenia. COMT rs4680 AA carriers and rs737865 AA carriers scored lowest on the Keep Track Task. When the genotype*group interaction effect was evaluated, rs165599 exerted opposite effects for VWM and Keep Track task performance in patients and controls, with AA carriers scoring lowest on both tests among controls, but highest among patients. These data support the hypothesis that COMT polymorphisms may be associated with schizophrenia and modulate cognition in patients and controls.

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Mendeley readers

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Geographical breakdown

Country Count As %
Unknown 41 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 10 24%
Student > Bachelor 7 17%
Researcher 6 15%
Student > Ph. D. Student 5 12%
Student > Doctoral Student 3 7%
Other 4 10%
Unknown 6 15%
Readers by discipline Count As %
Medicine and Dentistry 8 20%
Neuroscience 7 17%
Agricultural and Biological Sciences 5 12%
Biochemistry, Genetics and Molecular Biology 5 12%
Psychology 5 12%
Other 3 7%
Unknown 8 20%