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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Catechol-O-methyltransferase (COMT) polymorphisms modulate working memory in individuals with schizophrenia and healthy controls
|
|---|---|
| Published in |
Revista Brasileira de Psiquiatria, December 2017
|
| DOI | 10.1590/1516-4446-2016-1987 |
| Pubmed ID | |
| Authors |
Camila T. Matsuzaka, Denise Christofolini, Vanessa K. Ota, Ary Gadelha, Arthur A. Berberian, Cristiano Noto, Diego R. Mazzotti, Leticia M. Spindola, Patricia N. Moretti, Marilia A.C. Smith, Maria I. Melaragno, Sintia I. Belangero, Rodrigo A. Bressan |
| Abstract |
Cognitive impairment is a core feature of schizophrenia, related to dopaminergic dysfunction in the prefrontal cortex (PFC). It is hypothesized that functional single nucleotide polymorphism (SNP) rs4680 of the catechol-O-methyltransferase (COMT) gene could mediate the relationship between cognition and dopamine activity in the PFC. Other COMT SNPs could also play a role. We evaluated the role of three COMT SNPs (rs737865, rs165599, and rs4680) in schizophrenia and their impact on three working memory tasks. For genetic association analyses, 212 individuals with schizophrenia and 257 healthy controls (HCs) were selected. The Visual Working Memory (VWM) Task, Keep Track Task, and Letter Memory Task were administered to 133 schizophrenics and 93 HCs. We found a significant association of rs737865, with the GG genotype exerting a protective effect and the GA haplotype (rs4680/rs165599) exerting a risk effect for schizophrenia. COMT rs4680 AA carriers and rs737865 AA carriers scored lowest on the Keep Track Task. When the genotype*group interaction effect was evaluated, rs165599 exerted opposite effects for VWM and Keep Track task performance in patients and controls, with AA carriers scoring lowest on both tests among controls, but highest among patients. These data support the hypothesis that COMT polymorphisms may be associated with schizophrenia and modulate cognition in patients and controls. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 61 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 61 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Master | 10 | 16% |
| Student > Bachelor | 7 | 11% |
| Researcher | 7 | 11% |
| Student > Ph. D. Student | 7 | 11% |
| Student > Doctoral Student | 6 | 10% |
| Other | 9 | 15% |
| Unknown | 15 | 25% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 10 | 16% |
| Medicine and Dentistry | 8 | 13% |
| Agricultural and Biological Sciences | 6 | 10% |
| Biochemistry, Genetics and Molecular Biology | 6 | 10% |
| Psychology | 5 | 8% |
| Other | 9 | 15% |
| Unknown | 17 | 28% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 December 2017.
All research outputs
#22,764,772
of 25,382,440 outputs
Outputs from Revista Brasileira de Psiquiatria
#792
of 903 outputs
Outputs of similar age
#384,359
of 444,941 outputs
Outputs of similar age from Revista Brasileira de Psiquiatria
#10
of 11 outputs
Altmetric has tracked 25,382,440 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 903 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.9. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
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We're also able to compare this research output to 11 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.