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CXCL10 induces the recruitment of monocyte-derived macrophages into kidney, which aggravate puromycin aminonucleoside nephrosis

Overview of attention for article published in Clinical & Experimental Immunology, April 2015
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Title
CXCL10 induces the recruitment of monocyte-derived macrophages into kidney, which aggravate puromycin aminonucleoside nephrosis
Published in
Clinical & Experimental Immunology, April 2015
DOI 10.1111/cei.12579
Pubmed ID
Authors

D. Petrovic-Djergovic, M. Popovic, S. Chittiprol, H. Cortado, R. F. Ransom, S. Partida-Sánchez

Abstract

The mechanism responsible for trafficking of monocyte-derived macrophages into kidney in the puromycin aminonucleoside model of nephrotic syndrome in rats (PAN-NS), and the significance of this infiltration, remain largely unknown. CXCL10, a chemokine secreted in many Th1-type inflammatory diseases, exhibits important roles in trafficking of monocytes and activated T-cells. We hypothesized that induction of circulating IFN-γ and glomerular TNF-α during PAN-NS would stimulate release of CXCL10 by podocytes, leading to infiltration of activated immune cells and greater glomerular injury. We found that serum IFN-γ, glomerular Cxcl10 mRNA, and intra- and peri-glomerular macrophage infiltration were strongly induced during the late acute phase of PAN-NS in Wistar rats, but not in nude (Foxn1rnu/rnu) rats lacking functional effector T-lymphocytes. Wistar rats also developed significantly greater proteinuria than nude rats, which could be abolished by macrophage depletion. Stimulation of cultured podocytes with both IFN-γ and TNF-α markedly induced the expression of Cxcl10 mRNA and CXCL10 secretion. Together, these data support our hypothesis that increased circulating IFN-γ and glomerular TNF-α synergistically induce the production and secretion of CXCL10 by podocytes, attracting activated macrophages into kidney tissue. The study also suggests that IFN-γ, secreted from Th1 lymphocytes, may prime pro-inflammatory macrophages that consequently aggravate renal injury.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 28 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 28 100%

Demographic breakdown

Readers by professional status Count As %
Student > Master 9 32%
Student > Ph. D. Student 7 25%
Student > Bachelor 3 11%
Student > Postgraduate 2 7%
Researcher 2 7%
Other 2 7%
Unknown 3 11%
Readers by discipline Count As %
Medicine and Dentistry 8 29%
Agricultural and Biological Sciences 7 25%
Immunology and Microbiology 4 14%
Biochemistry, Genetics and Molecular Biology 4 14%
Unknown 5 18%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 30 June 2015.
All research outputs
#3,728,973
of 5,296,465 outputs
Outputs from Clinical & Experimental Immunology
#736
of 1,100 outputs
Outputs of similar age
#124,465
of 183,698 outputs
Outputs of similar age from Clinical & Experimental Immunology
#39
of 55 outputs
Altmetric has tracked 5,296,465 research outputs across all sources so far. This one is in the 16th percentile – i.e., 16% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,100 research outputs from this source. They receive a mean Attention Score of 3.0. This one is in the 20th percentile – i.e., 20% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 183,698 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 20th percentile – i.e., 20% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 55 others from the same source and published within six weeks on either side of this one. This one is in the 20th percentile – i.e., 20% of its contemporaries scored the same or lower than it.