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[Clinical-pathological features and survival in young women with cervical cancer: a retrospective analysis from the instituto nacional de enfermedades neoplásicas].

Overview of attention for article published in Revista peruana de medicina experimental y salud publica, January 2017
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Title
[Clinical-pathological features and survival in young women with cervical cancer: a retrospective analysis from the instituto nacional de enfermedades neoplásicas].
Published in
Revista peruana de medicina experimental y salud publica, January 2017
DOI 10.17843/rpmesp.2017.342.2653
Pubmed ID
Authors

Ruiz, Rossana, Serrano, Mariana, Ruiz, Eloy F, Mantilla, Raul, Valdivieso, Natalia, Olivera, Mivael, Álvarez, Manuel, Mas, Luis, Gomez, Henry L

Abstract

To determine the clinical and histological characteristics and prognostic factors of cervical cancer (CC) in young Peruvian patients. Retrospective analysis of patients younger than 35 years old diagnosed with CC between 2008 and 2012 in the Instituto Nacional de Enfermedades Neoplásicas. 449 patients had epithelial neoplasms. The main histological types were: squamous cell carcinoma (84.9%), adenocarcinoma (11.0%) and adenosquamous carcinoma (2.4%). The average tumor size was 4.98 cm. Anemia (55.7%), elevated creatinine (21.2%) and hydronephrosis (13.8%) were also identified. 82.3% of the patients presented locally advanced disease. Stages IIB (47.4%) and IIIB (25.8%) were the most common. Overall 5-year survival was 59.5% (I, 90.9%; II, 57.5%; III, 42.7% and IV, 13.3%). Elevated creatinine, anemia, tumor size, parametrial involvement and hydronephrosis were factors that affected survival. No significant relation was found between histological type and survival. The presence of anemia (adjusted hazard ratio [aHR]: 2.5; 95% confidence interval [CI 95%]: 1.6-4.0) and hydronephrosis (aHR: 1.6; CI 95%: 1.0-4.0) were independently associated with survival; likewise, the parametrial commitment with (aHR: 3.3; CI 95%: 1.5-7.2) or without (aRH: 2.6; CI 95%: 1.3-5.3) extension to the pelvic bone. Cervical cancer in young Peruvians is diagnosed in advanced stages. Overall survival in each stage is similar to the reported in older patients. The importance of conventional prognosis- related factors was confirmed. Anemia was an important independent prognostic factor requiring further investigations.

Mendeley readers

The data shown below were compiled from readership statistics for 24 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 24 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 8 33%
Student > Postgraduate 3 13%
Other 3 13%
Researcher 2 8%
Student > Doctoral Student 1 4%
Other 3 13%
Unknown 4 17%
Readers by discipline Count As %
Medicine and Dentistry 9 38%
Nursing and Health Professions 2 8%
Biochemistry, Genetics and Molecular Biology 2 8%
Economics, Econometrics and Finance 1 4%
Unspecified 1 4%
Other 4 17%
Unknown 5 21%