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Antioxidant effect of Morus nigra on Chagas disease progression

Overview of attention for article published in Revista do Instituto de Medicina Tropical de Sao Paulo, November 2017
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  • Above-average Attention Score compared to outputs of the same age and source (61st percentile)

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2 tweeters

Citations

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4 Dimensions

Readers on

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15 Mendeley
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Title
Antioxidant effect of Morus nigra on Chagas disease progression
Published in
Revista do Instituto de Medicina Tropical de Sao Paulo, November 2017
DOI 10.1590/s1678-9946201759073
Pubmed ID
Authors

Michelly Cristina Montenote, Vithor Zuccaro Wajsman, Yoichi Takaki Konno, Paulo César Ferreira, Regildo Márcio Gonçalves Silva, Altino Luiz Silva Therezo, Luciana Pereira Silva, Luciamáre Perinetti Alves Martins

Abstract

Considering the widespread popular use of Morus nigra and the amount of scientific information on its antioxidant and anti-inflammatory activity, the effectiveness of this phytotherapeutic compound in the parasitemia progression during the acute phase of Chagas disease and its role in the development of the inflammatory process as well as its effects on the oxidative damage in the chronic phase of infection were evaluated. Thus, 96 male Swiss mice were randomly divided into eight groups, four groups were uninfected controls, and four groups were intraperitoneally infected with 5.0 x 104 blood trypomastigotes forms of T. cruzi QM2 strain. Four batches composed of one uninfected and one infected group were respectively treated with 70% alcohol solution and 25 μL, 50 μL and 75 μL of the phytotherapeutic compound. Levels of antioxidant elements (TBARS, FRAP, GSH and Sulfhydryl groups) were measured in plasma samples. The phytotherapeutic compound's antioxidant activity was measured by polyphenol and total flavonoid quantification, DPPH, NO, and FRAP method. Our results showed that the vehicle influenced some of the results that may have physiological relevance in Chagas disease. However, an important action of M. nigra tincture was observed in the progression of Chagas disease, since our results demonstrated a reduction in parasitemia of treated groups when compared to controls, especially in the group receiving 25 µL. However, in the chronic phase, the 50-µL dosage presented a better activity on some antioxidant defenses and minimized the tissue inflammatory process. Results indicated an important action of M. nigra tincture on the Chagas disease progression.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 15 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 15 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 3 20%
Student > Bachelor 3 20%
Student > Doctoral Student 1 7%
Other 1 7%
Researcher 1 7%
Other 1 7%
Unknown 5 33%
Readers by discipline Count As %
Medicine and Dentistry 3 20%
Pharmacology, Toxicology and Pharmaceutical Science 2 13%
Agricultural and Biological Sciences 2 13%
Biochemistry, Genetics and Molecular Biology 1 7%
Neuroscience 1 7%
Other 0 0%
Unknown 6 40%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 17 December 2017.
All research outputs
#13,897,952
of 21,592,309 outputs
Outputs from Revista do Instituto de Medicina Tropical de Sao Paulo
#332
of 622 outputs
Outputs of similar age
#224,188
of 395,563 outputs
Outputs of similar age from Revista do Instituto de Medicina Tropical de Sao Paulo
#8
of 21 outputs
Altmetric has tracked 21,592,309 research outputs across all sources so far. This one is in the 35th percentile – i.e., 35% of other outputs scored the same or lower than it.
So far Altmetric has tracked 622 research outputs from this source. They receive a mean Attention Score of 3.0. This one is in the 48th percentile – i.e., 48% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 395,563 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 42nd percentile – i.e., 42% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 21 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 61% of its contemporaries.