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X Demographics
Mendeley readers
Attention Score in Context
| Title |
Antipurinergic therapy corrects the autism-like features in the Fragile X (Fmr1 knockout) mouse model
|
|---|---|
| Published in |
Molecular Autism, January 2015
|
| DOI | 10.1186/2040-2392-6-1 |
| Pubmed ID | |
| Authors |
Jane C Naviaux, Lin Wang, Kefeng Li, A Taylor Bright, William A Alaynick, Kenneth R Williams, Susan B Powell, Robert K Naviaux |
| Abstract |
Are the symptoms of autism caused by a treatable metabolic syndrome that traces to the abnormal persistence of a normal, alternative functional state of mitochondria? A small clinical trial published in 2017 suggests this is possible. Based on a new unifying theory of pathogenesis for autism called the cell danger response (CDR) hypothesis, this study of 10 boys, ages 5-14years, showed that all 5 boys who received antipurinergic therapy (APT) with a single intravenous dose of suramin experienced improvements in all the core symptoms of autism that lasted for 6-8weeks. Language, social interaction, restricted interests, and repetitive movements all improved. None of these improvements were observed in the placebo group. Larger and longer studies are needed to confirm this promising discovery. This review introduces the concept of M2 (anti-inflammatory) and M1 (pro-inflammatory) mitochondria that are polarized along a functional continuum according to cell stress. The pathophysiology of the CDR, the complementary functions of M1 and M2 mitochondria, relevant gene-environment interactions, and the metabolic underpinnings of behavior are discussed as foundation stones for understanding the improvements in ASD behaviors produced by antipurinergic therapy in this small clinical trial. |
X Demographics
The data shown below were collected from the profiles of 15 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 3 | 20% |
| United Kingdom | 2 | 13% |
| Canada | 2 | 13% |
| Unknown | 8 | 53% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 10 | 67% |
| Practitioners (doctors, other healthcare professionals) | 3 | 20% |
| Scientists | 1 | 7% |
| Science communicators (journalists, bloggers, editors) | 1 | 7% |
Mendeley readers
The data shown below were compiled from readership statistics for 175 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Chile | 1 | <1% |
| Unknown | 174 | 99% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Researcher | 31 | 18% |
| Student > Ph. D. Student | 28 | 16% |
| Student > Bachelor | 20 | 11% |
| Student > Master | 16 | 9% |
| Student > Doctoral Student | 13 | 7% |
| Other | 31 | 18% |
| Unknown | 36 | 21% |
| Readers by discipline | Count | As % |
|---|---|---|
| Agricultural and Biological Sciences | 33 | 19% |
| Biochemistry, Genetics and Molecular Biology | 25 | 14% |
| Neuroscience | 21 | 12% |
| Medicine and Dentistry | 21 | 12% |
| Psychology | 8 | 5% |
| Other | 23 | 13% |
| Unknown | 44 | 25% |
Attention Score in Context
This research output has an Altmetric Attention Score of 166. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 06 September 2023.
All research outputs
#245,369
of 25,460,285 outputs
Outputs from Molecular Autism
#26
of 720 outputs
Outputs of similar age
#2,792
of 360,794 outputs
Outputs of similar age from Molecular Autism
#1
of 11 outputs
Altmetric has tracked 25,460,285 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 99th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 720 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 28.2. This one has done particularly well, scoring higher than 96% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 360,794 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 11 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 99% of its contemporaries.