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X Demographics
Mendeley readers
Attention Score in Context
| Title |
A role for 2-Cys peroxiredoxins in facilitating cytosolic protein thiol oxidation
|
|---|---|
| Published in |
Nature Chemical Biology, December 2017
|
| DOI | 10.1038/nchembio.2536 |
| Pubmed ID | |
| Authors |
Sarah Stöcker, Michael Maurer, Thomas Ruppert, Tobias P Dick |
| Abstract |
Hydrogen peroxide (H2O2) acts as a signaling messenger by triggering the reversible oxidation of redox-regulated proteins. It remains unclear how proteins can be oxidized by signaling levels of H2O2 in the presence of peroxiredoxins, which are highly efficient peroxide scavengers. Here we show that the rapid formation of disulfide bonds in cytosolic proteins is enabled, rather than competed, by cytosolic 2-Cys peroxiredoxins. Under the conditions tested, the combined deletion or depletion of cytosolic peroxiredoxins broadly frustrated H2O2-dependent protein thiol oxidation, which is the exact opposite of what would be predicted based on the assumption that H2O2 oxidizes proteins directly. We find that peroxiredoxins enable rapid and sensitive protein thiol oxidation by relaying H2O2-derived oxidizing equivalents to other proteins. Although these findings do not rule out the existence of Prx-independent H2O2 signaling mechanisms, they suggest a broader role for peroxiredoxins as sensors and transmitters of H2O2 signals than hitherto recognized. |
X Demographics
The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 1 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 100% |
Mendeley readers
The data shown below were compiled from readership statistics for 144 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 144 | 100% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 21 | 15% |
| Researcher | 19 | 13% |
| Student > Bachelor | 15 | 10% |
| Student > Doctoral Student | 14 | 10% |
| Student > Master | 14 | 10% |
| Other | 20 | 14% |
| Unknown | 41 | 28% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 51 | 35% |
| Agricultural and Biological Sciences | 21 | 15% |
| Chemistry | 8 | 6% |
| Medicine and Dentistry | 3 | 2% |
| Business, Management and Accounting | 2 | 1% |
| Other | 11 | 8% |
| Unknown | 48 | 33% |
Attention Score in Context
This research output has an Altmetric Attention Score of 10. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 21 July 2020.
All research outputs
#3,231,984
of 23,012,811 outputs
Outputs from Nature Chemical Biology
#1,591
of 3,075 outputs
Outputs of similar age
#74,018
of 439,953 outputs
Outputs of similar age from Nature Chemical Biology
#30
of 43 outputs
Altmetric has tracked 23,012,811 research outputs across all sources so far. Compared to these this one has done well and is in the 85th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 3,075 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 25.4. This one is in the 47th percentile – i.e., 47% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 439,953 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 83% of its contemporaries.
We're also able to compare this research output to 43 others from the same source and published within six weeks on either side of this one. This one is in the 30th percentile – i.e., 30% of its contemporaries scored the same or lower than it.