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Benznidazole affects expression of Th1, Th17 and Treg cytokines during acute experimental Trypanosoma cruzi infection

Overview of attention for article published in Journal of Venomous Animals and Toxins including Tropical Diseases, December 2017
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Title
Benznidazole affects expression of Th1, Th17 and Treg cytokines during acute experimental Trypanosoma cruzi infection
Published in
Journal of Venomous Animals and Toxins including Tropical Diseases, December 2017
DOI 10.1186/s40409-017-0137-4
Pubmed ID
Authors

Mariana Gatto, Larissa Ragozo Cardoso Oliveira, Fernanda De Nuzzi Dias, João Pessoa Araújo Júnior, Carlos Roberto Gonçalves Lima, Eliana Peresi Lordelo, Rodrigo Mattos dos Santos, Cilmery Suemi Kurokawa

Abstract

The present study evaluated the effect of treatment with benznidazole on mRNA expression of IFN-γ, IL-17, IL-10, TGF-β and FoxP3 in spleen and heart tissue of BALB/c mice in the acute phase of an experimental infection with Trypanosoma cruzi, strains JLP or Y. The mRNA expression of cytokines and parasite load were assessed by q-PCR. Dependent groups were compared using Student's paired t-test and independent groups were compared using Student's unpaired t-test. Infection with the JLP or Y strains increased expression of IFN-γ in the heart and of IL-10 and IL-17 in the spleen and heart compared to uninfected animals. Treatment increased the expression of IFN-γ and decreased the expression of IL-17, IL-10, TGF- β and Foxp3 in spleen and heart tissue compared to untreated infected animals. Benznidazole can induce Th1 profile in the initial of the acute phase. The treatment decreased the parasite load in both organs, although the number of parasites in Y-strain-infected mice remained high. The data suggest that benznidazole may modulate cytokine expression in infection and can be dependent of the strain. However, treatment was not fully effective in the infection provoked by Y strain, probably due to the characteristics of the strain itself.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 24 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 24 100%

Demographic breakdown

Readers by professional status Count As %
Student > Doctoral Student 6 25%
Student > Bachelor 6 25%
Student > Ph. D. Student 3 13%
Student > Master 2 8%
Researcher 1 4%
Other 3 13%
Unknown 3 13%
Readers by discipline Count As %
Immunology and Microbiology 6 25%
Medicine and Dentistry 4 17%
Pharmacology, Toxicology and Pharmaceutical Science 3 13%
Biochemistry, Genetics and Molecular Biology 2 8%
Chemistry 2 8%
Other 3 13%
Unknown 4 17%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 20 December 2017.
All research outputs
#9,848,722
of 12,330,736 outputs
Outputs from Journal of Venomous Animals and Toxins including Tropical Diseases
#270
of 318 outputs
Outputs of similar age
#247,837
of 346,704 outputs
Outputs of similar age from Journal of Venomous Animals and Toxins including Tropical Diseases
#6
of 7 outputs
Altmetric has tracked 12,330,736 research outputs across all sources so far. This one is in the 11th percentile – i.e., 11% of other outputs scored the same or lower than it.
So far Altmetric has tracked 318 research outputs from this source. They receive a mean Attention Score of 3.1. This one is in the 4th percentile – i.e., 4% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 346,704 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 17th percentile – i.e., 17% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 7 others from the same source and published within six weeks on either side of this one.