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Heart regeneration in adult Xenopus tropicalis after apical resection

Overview of attention for article published in Cell & Bioscience, December 2017
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Title
Heart regeneration in adult Xenopus tropicalis after apical resection
Published in
Cell & Bioscience, December 2017
DOI 10.1186/s13578-017-0199-6
Pubmed ID
Authors

Souqi Liao, Wenyan Dong, Luocheng Lv, Hongyan Guo, Jifeng Yang, Hui Zhao, Ruijin Huang, Ziqiang Yuan, Yilin Chen, Shanshan Feng, Xin Zheng, Junqi Huang, Weihuan Huang, Xufeng Qi, Dongqing Cai

Abstract

Myocardium regeneration in adult mammals is very limited, but has enormous therapeutic potentials. However, we are far from complete understanding the cellular and molecular mechanisms by which heart tissue can regenerate. The full functional ability of amphibians to regenerate makes them powerful animal models for elucidating how damaged mature organs are naturally reconstituted in an adult organism. Like other amphibians, such as newts and axolotls, adult Xenopus displays high regenerative capacity such as retina. So far, whether the adult frog heart processes regenerative capacity after injury has not been well delineated. We examined the regeneration of adult cardiac tissues of Xenopus tropicalis after resection of heart apex. We showed, for the first time, that the adult X. tropicalis heart can regenerate perfectly in a nearly scar-free manner approximately 30 days after injury via apical resection. We observed that the injured heart was sealed through coagulation immediately after resection, which was followed by transient fibrous tissue production. Finally, the amputated area was regenerated by cardiomyocytes. During the regeneration process, the cardiomyocytes in the border area of the myocardium adjacent to the wound exhibited high proliferation after injury, thus contribute the newly formed heart tissue. Establishing a cardiac regeneration model in adult X. tropicalis provides a powerful tool for recapitulating a perfect regeneration phenomenon and elucidating the underlying molecular mechanisms of cardiac regeneration in an adult heart, and findings from this model may be applicable in mammals.

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Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 47 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 47 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 9 19%
Student > Bachelor 8 17%
Researcher 4 9%
Student > Master 3 6%
Other 2 4%
Other 8 17%
Unknown 13 28%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 18 38%
Agricultural and Biological Sciences 5 11%
Medicine and Dentistry 4 9%
Engineering 2 4%
Immunology and Microbiology 2 4%
Other 3 6%
Unknown 13 28%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 December 2017.
All research outputs
#15,486,175
of 23,012,811 outputs
Outputs from Cell & Bioscience
#412
of 944 outputs
Outputs of similar age
#266,570
of 439,212 outputs
Outputs of similar age from Cell & Bioscience
#5
of 14 outputs
Altmetric has tracked 23,012,811 research outputs across all sources so far. This one is in the 22nd percentile – i.e., 22% of other outputs scored the same or lower than it.
So far Altmetric has tracked 944 research outputs from this source. They receive a mean Attention Score of 3.7. This one is in the 49th percentile – i.e., 49% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 439,212 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 30th percentile – i.e., 30% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 14 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 64% of its contemporaries.