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FOCAL ENHANCED GASTRITIS AND MACROPHAGE MICROAGGREGATES IN THE GASTRIC MUCOSA: potential role in the differential diagnosis between Crohn’s disease and ulcerative colitis

Overview of attention for article published in Arquivos de Gastroenterologia, December 2014
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Title
FOCAL ENHANCED GASTRITIS AND MACROPHAGE MICROAGGREGATES IN THE GASTRIC MUCOSA: potential role in the differential diagnosis between Crohn’s disease and ulcerative colitis
Published in
Arquivos de Gastroenterologia, December 2014
DOI 10.1590/s0004-28032014000400003
Pubmed ID
Authors

Marcia Henriques de MAGALHÃES-COSTA, Beatriz Ribeiro dos REIS, Vera Lúcia Antunes CHAGAS, Tiago NUNES, Heitor Siffert Pereira de SOUZA, Cyrla ZALTMAN

Abstract

Context and Objectives Focally enhanced gastritis and macrophage microaggregates are found in the upper gastrointestinal involvement of Crohn's disease, and may reflect an underlying defective innate immunity. These features, however, are also described in patients with Helicobacter pylori infection. The role of these gastric abnormalities in the diagnosis of Crohn's disease was assessed in a population with high prevalence of H. pylori infection. Methods Thirty-seven Crohn's disease, 26 ulcerative colitis, and 30 control patients were included. The H. pylori status was evaluated by the rapid urease test and histology. The presence of focally enhanced gastritis and macrophage microaggregates was recorded. Results Focally enhanced gastritis was present in 24% of Crohn's disease patients, 4% of ulcerative colitis patients and 11.5% of controls, presenting an overall sensitivity and specificity for Crohn's disease of 24% and 88%, respectively. Macrophage microaggregates were found in all groups, but were only detected in ulcerative colitis and controls in association with H. pylori infection, with an overall sensitivity and specificity for Crohn's disease of 61% and 69%, respectively. In the absence of H. pylori infection, focally enhanced gastritis and macrophage microaggregates were significantly associated with Crohn's disease (P<0.02 and P = 0.001 respectively). Conclusions Focally gastritis and macrophage microaggregates are suggestive of Crohn's disease only in H. pylori-negative specimens. HEADINGS - Crohn's disease. Ulcerative colitis. Gastritis. Macrophages. Helicobacter pylori.

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Mendeley readers

The data shown below were compiled from readership statistics for 20 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 20 100%

Demographic breakdown

Readers by professional status Count As %
Student > Bachelor 6 30%
Student > Postgraduate 4 20%
Student > Master 2 10%
Student > Doctoral Student 1 5%
Other 1 5%
Other 2 10%
Unknown 4 20%
Readers by discipline Count As %
Medicine and Dentistry 10 50%
Biochemistry, Genetics and Molecular Biology 2 10%
Computer Science 1 5%
Psychology 1 5%
Agricultural and Biological Sciences 1 5%
Other 1 5%
Unknown 4 20%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 January 2015.
All research outputs
#11,136,561
of 12,520,820 outputs
Outputs from Arquivos de Gastroenterologia
#122
of 142 outputs
Outputs of similar age
#220,351
of 270,679 outputs
Outputs of similar age from Arquivos de Gastroenterologia
#1
of 1 outputs
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