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Secreted factors from metastatic prostate cancer cells stimulate mesenchymal stem cell transition to a pro-tumourigenic ‘activated’ state that enhances prostate cancer cell migration

Overview of attention for article published in International Journal of Cancer, January 2018
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • Good Attention Score compared to outputs of the same age (74th percentile)
  • Good Attention Score compared to outputs of the same age and source (78th percentile)

Mentioned by

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5 tweeters
googleplus
1 Google+ user

Citations

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12 Dimensions

Readers on

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24 Mendeley
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Title
Secreted factors from metastatic prostate cancer cells stimulate mesenchymal stem cell transition to a pro-tumourigenic ‘activated’ state that enhances prostate cancer cell migration
Published in
International Journal of Cancer, January 2018
DOI 10.1002/ijc.31226
Pubmed ID
Authors

Sarah M. Ridge, Dibyangana Bhattacharyya, Eoin Dervan, Serika D. Naicker, Amy J. Burke, J.M. Murphy, Karen O'leary, John Greene, Aideen E. Ryan, Francis J. Sullivan, Sharon A. Glynn

Abstract

Mesenchymal stem cells (MSCs) are a heterogeneous population of multipotent cells that are capable of differentiating into osteocytes, chondrocytes and adipocytes. Recently, MSCs have been found to home to the tumour site and engraft in the tumour stroma. However, it is not yet known whether they have a tumour promoting or suppressive function. We investigated the interaction between prostate cancer cell lines 22Rv1, DU145 and PC3, and bone marrow-derived MSCs. MSCs were 'educated' for extended periods in prostate cancer cell conditioned media and PC3-educated MSCs were found to be the most responsive with a secretory profile rich in pro-inflammatory cytokines. PC3-educated MSCs secreted increased osteopontin (OPN), interleukin-8 (IL-8) and fibroblast growth factor-2 (FGF-2) and decreased soluble fms-like tyrosine kinase-1 (sFlt-1) compared to untreated MSCs. PC3-educated MSCs showed a reduced migration and proliferation capacity that was dependent on exposure to PC3-conditioned medium. Vimentin and α-smooth muscle actin (αSMA) expression was decreased in PC3-educated MSCs compared to untreated MSCs. PC3 and DU145 education of healthy donor and prostate cancer patient derived MSCs led to a reduced proportion of FAP+ αSMA+ cells contrary to characteristics commonly associated with cancer associated fibroblasts (CAFs). The migration of PC3 cells was increased towards both PC3-educated and DU145-educated MSCs compared to untreated MSCs, while DU145 migration was only enhanced towards patient derived MSCs In summary, MSCs developed an altered phenotype in response to prostate cancer conditioned medium which resulted in increased secretion of pro-inflammatory cytokines, modified the functional activity and the chemoattraction of prostate cancer cells. This article is protected by copyright. All rights reserved.

Twitter Demographics

The data shown below were collected from the profiles of 5 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 24 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 24 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 7 29%
Student > Bachelor 4 17%
Student > Ph. D. Student 4 17%
Student > Master 3 13%
Professor > Associate Professor 2 8%
Other 4 17%
Readers by discipline Count As %
Medicine and Dentistry 5 21%
Biochemistry, Genetics and Molecular Biology 4 17%
Immunology and Microbiology 4 17%
Agricultural and Biological Sciences 3 13%
Pharmacology, Toxicology and Pharmaceutical Science 1 4%
Other 4 17%
Unknown 3 13%

Attention Score in Context

This research output has an Altmetric Attention Score of 6. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 December 2017.
All research outputs
#2,693,615
of 12,341,991 outputs
Outputs from International Journal of Cancer
#2,454
of 8,876 outputs
Outputs of similar age
#89,103
of 347,177 outputs
Outputs of similar age from International Journal of Cancer
#20
of 91 outputs
Altmetric has tracked 12,341,991 research outputs across all sources so far. Compared to these this one has done well and is in the 78th percentile: it's in the top 25% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 8,876 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.3. This one has gotten more attention than average, scoring higher than 72% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 347,177 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 74% of its contemporaries.
We're also able to compare this research output to 91 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 78% of its contemporaries.