Title |
Characterisation and manipulation of docetaxel resistant prostate cancer cell lines
|
---|---|
Published in |
Molecular Cancer, October 2011
|
DOI | 10.1186/1476-4598-10-126 |
Pubmed ID | |
Authors |
Amanda J O'Neill, Maria Prencipe, Catherine Dowling, Yue Fan, Laoighse Mulrane, William M Gallagher, Darran O'Connor, Robert O'Connor, Aoife Devery, Claire Corcoran, Sweta Rani, Lorraine O'Driscoll, John M Fitzpatrick, R William G Watson |
Abstract |
There is no effective treatment strategy for advanced castration-resistant prostate cancer. Although Docetaxel (Taxotere®) represents the most active chemotherapeutic agent it only gives a modest survival advantage with most patients eventually progressing because of inherent or acquired drug resistance. The aims of this study were to further investigate the mechanisms of resistance to Docetaxel. Three Docetaxel resistant sub-lines were generated and confirmed to be resistant to the apoptotic and anti-proliferative effects of increasing concentrations of Docetaxel. |
Mendeley readers
Geographical breakdown
Country | Count | As % |
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India | 1 | <1% |
Russia | 1 | <1% |
Unknown | 126 | 98% |
Demographic breakdown
Readers by professional status | Count | As % |
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Researcher | 21 | 16% |
Student > Master | 14 | 11% |
Student > Bachelor | 14 | 11% |
Other | 9 | 7% |
Other | 20 | 16% |
Unknown | 20 | 16% |
Readers by discipline | Count | As % |
---|---|---|
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Pharmacology, Toxicology and Pharmaceutical Science | 7 | 5% |
Engineering | 5 | 4% |
Other | 13 | 10% |
Unknown | 23 | 18% |