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Plasma complement component 4 increases in patients with major depressive disorder

Overview of attention for article published in Neuropsychiatric Disease and Treatment, December 2017
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  • Above-average Attention Score compared to outputs of the same age (51st percentile)
  • Average Attention Score compared to outputs of the same age and source

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4 tweeters
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2 Facebook pages

Citations

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2 Dimensions

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21 Mendeley
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Title
Plasma complement component 4 increases in patients with major depressive disorder
Published in
Neuropsychiatric Disease and Treatment, December 2017
DOI 10.2147/ndt.s151238
Pubmed ID
Authors

Jinxue Wei, Ye Liu, Liansheng Zhao, Xiao Yang, Peiyan Ni, Yingcheng Wang, Tao Li, Xiaohong Ma

Abstract

Elevation of plasma inflammatory factors in major depressive disorder (MDD) has been repeatedly observed, but contradictory results have also been reported. Alteration of complement components in MDD may also contribute to the pathophysiology of MDD by participating in inflammation. The recent findings that complement component 4 (C4) was involved in neural synapse elimination and associated with schizophrenia implicated the potential roles of C4 in MDD. In this study, we analyzed the plasma concentration of complement C4 and inflammatory factors, including interleukin (IL)-1β, IL-6, IL-8, IL-10, interferon-α, interferon-γ and tumor necrosis factor-α, of 53 patients with MDD and 60 healthy individuals. The plasma of 17 patients out of 51 after antidepressant medication was also collected for analysis. The results showed that peripheral C4 in MDD was higher than that in healthy controls. No significant correlation of inflammatory factors or C4 with depressive or anxiety symptoms was found. Antidepressant medication significantly reduced plasma C4 of patients with MDD. Our results were consistent with previous findings that complement components were elevated in MDD and suggested that C4 might play a role in pathophysiology of MDD and could be a candidate in the research of biomarker and the pathophysiology of MDD.

Twitter Demographics

The data shown below were collected from the profiles of 4 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 21 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 21 100%

Demographic breakdown

Readers by professional status Count As %
Unspecified 5 24%
Student > Doctoral Student 4 19%
Student > Bachelor 3 14%
Student > Postgraduate 2 10%
Student > Master 2 10%
Other 5 24%
Readers by discipline Count As %
Unspecified 7 33%
Biochemistry, Genetics and Molecular Biology 6 29%
Medicine and Dentistry 3 14%
Immunology and Microbiology 1 5%
Psychology 1 5%
Other 3 14%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 08 January 2018.
All research outputs
#7,682,584
of 13,615,716 outputs
Outputs from Neuropsychiatric Disease and Treatment
#1,047
of 2,349 outputs
Outputs of similar age
#180,921
of 390,537 outputs
Outputs of similar age from Neuropsychiatric Disease and Treatment
#33
of 70 outputs
Altmetric has tracked 13,615,716 research outputs across all sources so far. This one is in the 42nd percentile – i.e., 42% of other outputs scored the same or lower than it.
So far Altmetric has tracked 2,349 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 5.8. This one has gotten more attention than average, scoring higher than 51% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 390,537 tracked outputs that were published within six weeks on either side of this one in any source. This one has gotten more attention than average, scoring higher than 51% of its contemporaries.
We're also able to compare this research output to 70 others from the same source and published within six weeks on either side of this one. This one is in the 47th percentile – i.e., 47% of its contemporaries scored the same or lower than it.