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Cancer exosomes trigger mesenchymal stem cell differentiation into pro-angiogenic and pro-invasive myofibroblasts

Overview of attention for article published in Oncotarget, November 2014
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  • Good Attention Score compared to outputs of the same age and source (71st percentile)

Mentioned by

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2 tweeters

Citations

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186 Dimensions

Readers on

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243 Mendeley
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Title
Cancer exosomes trigger mesenchymal stem cell differentiation into pro-angiogenic and pro-invasive myofibroblasts
Published in
Oncotarget, November 2014
DOI 10.18632/oncotarget.2711
Pubmed ID
Authors

Ridwana Chowdhury, Jason P. Webber, Mark Gurney, Malcolm D. Mason, Zsuzsanna Tabi, Aled Clayton

Abstract

Stromal fibroblasts become altered in response to solid cancers, to exhibit myofibroblastic characteristics, with disease promoting influence. Infiltrating mesenchymal stem cells (MSC) may contribute towards these changes, but the factors secreted by cancer cells that impact MSC differentiation are poorly understood. We investigated the role of nano-metre sized vesicles (exosomes), secreted by prostate cancer cells, on the differentiation of bone-marrow MSC (BM-MSC), and the subsequent functional consequences of such changes. Purified exosomes impaired classical adipogenic differentiation, skewing differentiation towards alpha-smooth muscle actin (αSMA) positive myofibroblastic cells. A single exosomes treatment generated myofibroblasts secreting high levels of VEGF-A, HGF and matrix regulating factors (MMP-1, -3 and -13). Differentiated MSC had pro-angiogenic functions and enhanced tumour proliferation and invasivity assessed in a 3D co-culture model. Differentiation was dependent on exosomal-TGFβ, but soluble TGFβ at matched dose could not generate the same phenotype. Exosomes present in the cancer cell secretome were the principal factors driving this phenotype. Prostate cancer exosomes dominantly dictate a programme of MSC differentiation generating myofibroblasts with functional properties consistent with disease promotion.

Twitter Demographics

The data shown below were collected from the profiles of 2 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 243 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Denmark 2 <1%
United States 1 <1%
Portugal 1 <1%
Chile 1 <1%
Unknown 238 98%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 62 26%
Researcher 40 16%
Student > Master 39 16%
Student > Bachelor 30 12%
Other 11 5%
Other 28 12%
Unknown 33 14%
Readers by discipline Count As %
Biochemistry, Genetics and Molecular Biology 59 24%
Agricultural and Biological Sciences 57 23%
Medicine and Dentistry 44 18%
Engineering 8 3%
Pharmacology, Toxicology and Pharmaceutical Science 7 3%
Other 18 7%
Unknown 50 21%

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 15 June 2015.
All research outputs
#2,830,678
of 6,417,151 outputs
Outputs from Oncotarget
#1,200
of 5,865 outputs
Outputs of similar age
#95,009
of 203,956 outputs
Outputs of similar age from Oncotarget
#51
of 257 outputs
Altmetric has tracked 6,417,151 research outputs across all sources so far. This one has received more attention than most of these and is in the 53rd percentile.
So far Altmetric has tracked 5,865 research outputs from this source. They receive a mean Attention Score of 2.0. This one has gotten more attention than average, scoring higher than 72% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 203,956 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 49th percentile – i.e., 49% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 257 others from the same source and published within six weeks on either side of this one. This one has gotten more attention than average, scoring higher than 71% of its contemporaries.