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Attention Score in Context
| Title |
Heterogeneity of tremor mechanisms assessed by tremor-related cortical potential in mice
|
|---|---|
| Published in |
Molecular Brain, January 2015
|
| DOI | 10.1186/s13041-015-0093-2 |
| Pubmed ID | |
| Authors |
Young-Gyun Park, Jee Hyun Choi, Chungki Lee, Sehyun Kim, Youngsoo Kim, Ki-Young Chang, Sun Ha Paek, Daesoo Kim |
| Abstract |
BackgroundIdentifying a neural circuit mechanism that is differentially involved in tremor would aid in the diagnosis and cure of such cases. Here, we demonstrate that tremor-related cortical potential (TRCP) is differentially expressed in two different mouse models of tremor.ResultsHybrid tremor analysis of harmaline-induced and genetic tremor in mice revealed that two authentic tremor frequencies for each type of tremor were conserved and showed an opposite dependence on CaV3.1 T-type Ca2+ channels. Electroencephalogram recordings revealed that ¿1¿/¿;¿1G-/- mice double-null for the GABA receptor ¿1 subunit (Gabra1) and CaV3.1 T-type Ca2+ channels (Cacna1g), in which the tremor caused by the absence of Gabra1 is potentiated by the absence of Cacna1g, showed a coherent TRCP that exhibited an onset that preceded the initiation of behavioral tremor by 3 ms. However, harmaline-induced tremor, which is known to be abolished by ¿1G¿/¿, showed no TRCP.ConclusionsOur results demonstrate that the ¿1¿/¿;¿1G¿/¿ double-knockout tremor model is useful for studying cortical mechanisms of tremor. |
X Demographics
The data shown below were collected from the profiles of 2 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Unknown | 2 | 100% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 1 | 50% |
| Science communicators (journalists, bloggers, editors) | 1 | 50% |
Mendeley readers
The data shown below were compiled from readership statistics for 19 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| Iran, Islamic Republic of | 1 | 5% |
| Unknown | 18 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 5 | 26% |
| Researcher | 5 | 26% |
| Student > Master | 2 | 11% |
| Student > Bachelor | 1 | 5% |
| Student > Doctoral Student | 1 | 5% |
| Other | 0 | 0% |
| Unknown | 5 | 26% |
| Readers by discipline | Count | As % |
|---|---|---|
| Neuroscience | 5 | 26% |
| Medicine and Dentistry | 4 | 21% |
| Pharmacology, Toxicology and Pharmaceutical Science | 2 | 11% |
| Agricultural and Biological Sciences | 2 | 11% |
| Psychology | 1 | 5% |
| Other | 1 | 5% |
| Unknown | 4 | 21% |
Attention Score in Context
This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 22 January 2015.
All research outputs
#16,730,401
of 24,605,383 outputs
Outputs from Molecular Brain
#716
of 1,177 outputs
Outputs of similar age
#236,628
of 390,343 outputs
Outputs of similar age from Molecular Brain
#19
of 22 outputs
Altmetric has tracked 24,605,383 research outputs across all sources so far. This one is in the 21st percentile – i.e., 21% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,177 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.0. This one is in the 33rd percentile – i.e., 33% of its peers scored the same or lower than it.
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We're also able to compare this research output to 22 others from the same source and published within six weeks on either side of this one. This one is in the 13th percentile – i.e., 13% of its contemporaries scored the same or lower than it.