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Pharmacokinetics of chewed vs. swallowed raltegravir in a patient with AIDS and MAI infection: some new conflicting data

Overview of attention for article published in AIDS Research and Therapy, January 2015
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Title
Pharmacokinetics of chewed vs. swallowed raltegravir in a patient with AIDS and MAI infection: some new conflicting data
Published in
AIDS Research and Therapy, January 2015
DOI 10.1186/s12981-014-0041-8
Pubmed ID
Authors

Christoph D Spinner, Florian Wille, Christiane Schwerdtfeger, Philipp Thies, Ursula Tanase, Guido Von Figura, Roland M Schmid, Werner J Heinz, Hartwig Hf Klinker

Abstract

While HIV, AIDS and atypical Mycobacterium infections are closely linked, the use of Integrase-Inhibitor based cART, notably raltegravir-based regimens is more widespread. RAL should be double-dosed to 800 mg semi-daily in situation of rifampicin co-medication, because RAL is more rapidly metabolized due to rifampicin-induced Uridine-5'-diphosph- gluronosyl-transferase (UGT1A1). Recently, it was speculated that chewed RAL might lead to increased absorption, which might compensate the inductive effect of rifampicin-rapid metabolized RAL, as part of cost-saving effects in countries with high-tuberculosis prevalence and less economic power.

X Demographics

X Demographics

The data shown below were collected from the profiles of 5 X users who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 24 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
United States 1 4%
Brazil 1 4%
Unknown 22 92%

Demographic breakdown

Readers by professional status Count As %
Student > Master 5 21%
Researcher 4 17%
Student > Doctoral Student 2 8%
Other 2 8%
Lecturer 2 8%
Other 6 25%
Unknown 3 13%
Readers by discipline Count As %
Medicine and Dentistry 10 42%
Pharmacology, Toxicology and Pharmaceutical Science 2 8%
Social Sciences 2 8%
Environmental Science 1 4%
Immunology and Microbiology 1 4%
Other 3 13%
Unknown 5 21%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 2. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 16 February 2015.
All research outputs
#15,740,207
of 25,374,647 outputs
Outputs from AIDS Research and Therapy
#325
of 637 outputs
Outputs of similar age
#194,703
of 359,720 outputs
Outputs of similar age from AIDS Research and Therapy
#2
of 6 outputs
Altmetric has tracked 25,374,647 research outputs across all sources so far. This one is in the 37th percentile – i.e., 37% of other outputs scored the same or lower than it.
So far Altmetric has tracked 637 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 6.1. This one is in the 47th percentile – i.e., 47% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 359,720 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 44th percentile – i.e., 44% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 6 others from the same source and published within six weeks on either side of this one. This one has scored higher than 4 of them.