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X Demographics
Mendeley readers
Attention Score in Context
| Title |
A molecular census of 26S proteasomes in intact neurons
|
|---|---|
| Published in |
Science, January 2015
|
| DOI | 10.1126/science.1261197 |
| Pubmed ID | |
| Authors |
Shoh Asano, Yoshiyuki Fukuda, Florian Beck, Antje Aufderheide, Friedrich Förster, Radostin Danev, Wolfgang Baumeister |
| Abstract |
The 26S proteasome is a key player in eukaryotic protein quality control and in the regulation of numerous cellular processes. Here, we describe quantitative in situ structural studies of this highly dynamic molecular machine in intact hippocampal neurons. We used electron cryotomography with the Volta phase plate, which allowed high fidelity and nanometer precision localization of 26S proteasomes. We undertook a molecular census of single- and double-capped proteasomes and assessed the conformational states of individual complexes. Under the conditions of the experiment—that is, in the absence of proteotoxic stress—only 20% of the 26S proteasomes were engaged in substrate processing. The remainder was in the substrate-accepting ground state. These findings suggest that in the absence of stress, the capacity of the proteasome system is not fully used. |
X Demographics
The data shown below were collected from the profiles of 26 X users who shared this research output. Click here to find out more about how the information was compiled.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United Kingdom | 3 | 12% |
| United States | 3 | 12% |
| Canada | 1 | 4% |
| Central African Republic | 1 | 4% |
| China | 1 | 4% |
| Australia | 1 | 4% |
| Colombia | 1 | 4% |
| Sweden | 1 | 4% |
| Belgium | 1 | 4% |
| Other | 0 | 0% |
| Unknown | 13 | 50% |
Demographic breakdown
| Type | Count | As % |
|---|---|---|
| Members of the public | 17 | 65% |
| Scientists | 9 | 35% |
Mendeley readers
The data shown below were compiled from readership statistics for 286 Mendeley readers of this research output. Click here to see the associated Mendeley record.
Geographical breakdown
| Country | Count | As % |
|---|---|---|
| United States | 6 | 2% |
| Germany | 4 | 1% |
| United Kingdom | 2 | <1% |
| Korea, Republic of | 1 | <1% |
| Canada | 1 | <1% |
| Netherlands | 1 | <1% |
| Unknown | 271 | 95% |
Demographic breakdown
| Readers by professional status | Count | As % |
|---|---|---|
| Student > Ph. D. Student | 80 | 28% |
| Researcher | 58 | 20% |
| Student > Bachelor | 25 | 9% |
| Student > Master | 22 | 8% |
| Student > Doctoral Student | 13 | 5% |
| Other | 37 | 13% |
| Unknown | 51 | 18% |
| Readers by discipline | Count | As % |
|---|---|---|
| Biochemistry, Genetics and Molecular Biology | 86 | 30% |
| Agricultural and Biological Sciences | 79 | 28% |
| Neuroscience | 14 | 5% |
| Chemistry | 13 | 5% |
| Physics and Astronomy | 11 | 4% |
| Other | 25 | 9% |
| Unknown | 58 | 20% |
Attention Score in Context
This research output has an Altmetric Attention Score of 136. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 27 May 2023.
All research outputs
#309,016
of 25,692,343 outputs
Outputs from Science
#8,277
of 83,214 outputs
Outputs of similar age
#3,647
of 360,983 outputs
Outputs of similar age from Science
#187
of 1,170 outputs
Altmetric has tracked 25,692,343 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 98th percentile: it's in the top 5% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 83,214 research outputs from this source. They typically receive a lot more attention than average, with a mean Attention Score of 65.8. This one has done particularly well, scoring higher than 90% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 360,983 tracked outputs that were published within six weeks on either side of this one in any source. This one has done particularly well, scoring higher than 99% of its contemporaries.
We're also able to compare this research output to 1,170 others from the same source and published within six weeks on either side of this one. This one has done well, scoring higher than 84% of its contemporaries.