↓ Skip to main content

Chronic Treatment with Fluoxetine or Clozapine of Socially Isolated Rats Prevents Subsector-Specific Reduction of Parvalbumin Immunoreactive Cells in the Hippocampus

Overview of attention for article published in Neuroscience, February 2018
Altmetric Badge

Mentioned by

twitter
1 tweeter

Citations

dimensions_citation
18 Dimensions

Readers on

mendeley
34 Mendeley
You are seeing a free-to-access but limited selection of the activity Altmetric has collected about this research output. Click here to find out more.
Title
Chronic Treatment with Fluoxetine or Clozapine of Socially Isolated Rats Prevents Subsector-Specific Reduction of Parvalbumin Immunoreactive Cells in the Hippocampus
Published in
Neuroscience, February 2018
DOI 10.1016/j.neuroscience.2017.12.020
Pubmed ID
Authors

Dragana Filipović, Andrijana Stanisavljević, Nebojša Jasnić, Rick E. Bernardi, Dragos Inta, Ivana Perić, Peter Gass

Abstract

The dysfunction of parvalbumin-positive (PV+) interneurons, the most abundant type of hippocampal GABAergic inhibitory interneuron, has been implicated in mood disorders. We recently reported that adult male Wistar rats exposed to three weeks of social isolation show depressive- and anxiety-like behaviors and a reduced number of PV+ interneurons in all hippocampal subregions. As GABA neurotransmission has been proposed as a potential therapeutic target of antidepressant and antipsychotic medications, we examined whether treatment with the antidepressant fluoxetine (15 mg/kg/day) or the antipsychotic clozapine (20 mg/kg/day) during three weeks of social isolation in rats offered protection from the isolation stress-induced reduction in the number of PV+ interneurons in hippocampal subregions. Using immunofluorescence analysis, we revealed that both chronic fluoxetine and clozapine partially prevented the isolation-induced changes. Fluoxetine prevented the reduction in the number of PV+ interneurons in the CA2, CA3, without affecting the CA1 and dentate gyrus DG areas, whereas clozapine prevented this decrement in the CA2, CA3 and DG regions but not in CA1 areas. Moreover, fluoxetine increased the number of PV+ interneurons in CA1 in control animals. These findings suggest that chronic administration of fluoxetine or clozapine may offer partial protection from social isolation stress via modulation of the hippocampal GABAergic system.

Twitter Demographics

The data shown below were collected from the profile of 1 tweeter who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 34 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 34 100%

Demographic breakdown

Readers by professional status Count As %
Student > Ph. D. Student 5 15%
Student > Doctoral Student 5 15%
Other 4 12%
Student > Bachelor 3 9%
Professor 3 9%
Other 6 18%
Unknown 8 24%
Readers by discipline Count As %
Neuroscience 8 24%
Medicine and Dentistry 5 15%
Agricultural and Biological Sciences 5 15%
Biochemistry, Genetics and Molecular Biology 4 12%
Psychology 1 3%
Other 4 12%
Unknown 7 21%

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 26 December 2017.
All research outputs
#10,944,985
of 12,350,579 outputs
Outputs from Neuroscience
#4,854
of 5,534 outputs
Outputs of similar age
#289,583
of 349,037 outputs
Outputs of similar age from Neuroscience
#151
of 167 outputs
Altmetric has tracked 12,350,579 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 5,534 research outputs from this source. They receive a mean Attention Score of 4.3. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 349,037 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 167 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.