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Intracellular trafficking and endocytosis of CXCR4 in fetal mesenchymal stem/stromal cells

Overview of attention for article published in BMC Molecular and Cell Biology, May 2014
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Title
Intracellular trafficking and endocytosis of CXCR4 in fetal mesenchymal stem/stromal cells
Published in
BMC Molecular and Cell Biology, May 2014
DOI 10.1186/1471-2121-15-15
Pubmed ID
Authors

Rebecca A Pelekanos, Michael J Ting, Varda S Sardesai, Jennifer M Ryan, Yaw-Chyn Lim, Jerry KY Chan, Nicholas M Fisk

Abstract

Fetal mesenchymal stem/stromal cells (MSC) represent a developmentally-advantageous cell type with translational potential.To enhance adult MSC migration, studies have focussed on the role of the chemokine receptor CXCR4 and its ligand SDF-1 (CXCL12), but more recent work implicates an intricate system of CXCR4 receptor dimerization, intracellular localization, multiple ligands, splice variants and nuclear accumulation. We investigated the intracellular localization of CXCR4 in fetal bone marrow-derived MSC and role of intracellular trafficking in CXCR4 surface expression and function.

X Demographics

X Demographics

The data shown below were collected from the profile of 1 X user who shared this research output. Click here to find out more about how the information was compiled.
Mendeley readers

Mendeley readers

The data shown below were compiled from readership statistics for 99 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Spain 1 1%
United States 1 1%
India 1 1%
Singapore 1 1%
Unknown 95 96%

Demographic breakdown

Readers by professional status Count As %
Researcher 33 33%
Other 27 27%
Student > Ph. D. Student 7 7%
Student > Master 7 7%
Student > Doctoral Student 5 5%
Other 12 12%
Unknown 8 8%
Readers by discipline Count As %
Agricultural and Biological Sciences 51 52%
Biochemistry, Genetics and Molecular Biology 15 15%
Medicine and Dentistry 9 9%
Neuroscience 4 4%
Immunology and Microbiology 3 3%
Other 8 8%
Unknown 9 9%
Attention Score in Context

Attention Score in Context

This research output has an Altmetric Attention Score of 1. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 23 January 2015.
All research outputs
#22,756,649
of 25,371,288 outputs
Outputs from BMC Molecular and Cell Biology
#1,054
of 1,233 outputs
Outputs of similar age
#209,214
of 241,956 outputs
Outputs of similar age from BMC Molecular and Cell Biology
#10
of 14 outputs
Altmetric has tracked 25,371,288 research outputs across all sources so far. This one is in the 1st percentile – i.e., 1% of other outputs scored the same or lower than it.
So far Altmetric has tracked 1,233 research outputs from this source. They receive a mean Attention Score of 4.0. This one is in the 1st percentile – i.e., 1% of its peers scored the same or lower than it.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 241,956 tracked outputs that were published within six weeks on either side of this one in any source. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.
We're also able to compare this research output to 14 others from the same source and published within six weeks on either side of this one. This one is in the 1st percentile – i.e., 1% of its contemporaries scored the same or lower than it.