Title |
Evaluating the evidence for targeting FOXO3a in breast cancer: a systematic review
|
---|---|
Published in |
Cancer Cell International, January 2015
|
DOI | 10.1186/s12935-015-0156-6 |
Pubmed ID | |
Authors |
Simon Taylor, Matthew Lam, Chathyan Pararasa, James EP Brown, Amtul R Carmichael, Helen R Griffiths |
Abstract |
Tumour cells show greater dependency on glycolysis so providing a sufficient and rapid energy supply for fast growth. In many breast cancers, estrogen, progesterone and epidermal growth factor receptor-positive cells proliferate in response to growth factors and growth factor antagonists are a mainstay of treatment. However, triple negative breast cancer (TNBC) cells lack receptor expression, are frequently more aggressive and are resistant to growth factor inhibition. Downstream of growth factor receptors, signal transduction proceeds via phosphatidylinositol 3-kinase (PI3k), Akt and FOXO3a inhibition, the latter being partly responsible for coordinated increases in glycolysis and apoptosis resistance. FOXO3a may be an attractive therapeutic target for TNBC. Therefore we have undertaken a systematic review of FOXO3a as a target for breast cancer therapeutics. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 25% |
United Kingdom | 1 | 25% |
Unknown | 2 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 3 | 75% |
Scientists | 1 | 25% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Spain | 1 | 1% |
India | 1 | 1% |
Denmark | 1 | 1% |
Brazil | 1 | 1% |
Unknown | 73 | 95% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 15 | 19% |
Researcher | 14 | 18% |
Student > Ph. D. Student | 11 | 14% |
Professor | 8 | 10% |
Student > Bachelor | 5 | 6% |
Other | 13 | 17% |
Unknown | 11 | 14% |
Readers by discipline | Count | As % |
---|---|---|
Biochemistry, Genetics and Molecular Biology | 20 | 26% |
Medicine and Dentistry | 16 | 21% |
Agricultural and Biological Sciences | 15 | 19% |
Chemistry | 5 | 6% |
Nursing and Health Professions | 3 | 4% |
Other | 5 | 6% |
Unknown | 13 | 17% |