Title |
Oxidative DNA damage in diabetic and mild gestational hyperglycemic pregnant women
|
---|---|
Published in |
Diabetology & Metabolic Syndrome, January 2015
|
DOI | 10.1186/1758-5996-7-1 |
Pubmed ID | |
Authors |
Rafael Bottaro Gelaleti, Débora Cristina Damasceno, Paula Helena Ortiz Lima, Daisy Maria Favero Salvadori, Iracema de Mattos Paranhos Calderon, José Carlos Peraçoli, Marilza Vieira Cunha Rudge |
Abstract |
Pregnant women with mild gestational hyperglycemia present high risk for hypertension, obesity and hyperglycemia, and appeared to reproduce the model of metabolic syndrome in pregnancy, with hyperinsulinemia and insulin resistance. Our clinical studies showed that mild gestational hyperglycemia or gestational diabetes are related to similar adverse maternal and perinatal outcomes. Hyperglycemia and other factors associated with diabetes generate reactive oxygen species that increase DNA damage levels. The aim of this study was to evaluate oxidative DNA damage in lymphocytes of pregnant women with diabetes or mild gestational hyperglycemia. |
X Demographics
Geographical breakdown
Country | Count | As % |
---|---|---|
United States | 1 | 50% |
Unknown | 1 | 50% |
Demographic breakdown
Type | Count | As % |
---|---|---|
Members of the public | 2 | 100% |
Mendeley readers
Geographical breakdown
Country | Count | As % |
---|---|---|
Cuba | 1 | 2% |
India | 1 | 2% |
Unknown | 58 | 97% |
Demographic breakdown
Readers by professional status | Count | As % |
---|---|---|
Student > Master | 8 | 13% |
Researcher | 7 | 12% |
Student > Ph. D. Student | 5 | 8% |
Student > Postgraduate | 4 | 7% |
Student > Doctoral Student | 3 | 5% |
Other | 9 | 15% |
Unknown | 24 | 40% |
Readers by discipline | Count | As % |
---|---|---|
Medicine and Dentistry | 13 | 22% |
Biochemistry, Genetics and Molecular Biology | 7 | 12% |
Nursing and Health Professions | 5 | 8% |
Agricultural and Biological Sciences | 3 | 5% |
Pharmacology, Toxicology and Pharmaceutical Science | 1 | 2% |
Other | 4 | 7% |
Unknown | 27 | 45% |