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Cytokine signatures in chronic fatigue syndrome patients: a Case Control Study and the effect of anakinra treatment

Overview of attention for article published in Journal of Translational Medicine, December 2017
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About this Attention Score

  • In the top 25% of all research outputs scored by Altmetric
  • High Attention Score compared to outputs of the same age (88th percentile)
  • High Attention Score compared to outputs of the same age and source (91st percentile)

Mentioned by

twitter
29 tweeters
facebook
3 Facebook pages

Citations

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8 Dimensions

Readers on

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35 Mendeley
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Title
Cytokine signatures in chronic fatigue syndrome patients: a Case Control Study and the effect of anakinra treatment
Published in
Journal of Translational Medicine, December 2017
DOI 10.1186/s12967-017-1371-9
Pubmed ID
Authors

Megan E. Roerink, Hans Knoop, Ewald M. Bronkhorst, Henk A. Mouthaan, Luuk J. A. C. Hawinkels, Leo A. B. Joosten, Jos W. M. van der Meer

Abstract

Cytokine disturbances have been suggested to be associated with the Chronic Fatigue Syndrome/Myalgic encephalomyelitis (CFS/ME) for decades. Fifty female CFS patients were included in a study on the effect of the interleukin-1-receptor antagonist anakinra or placebo during 4 weeks. EDTA plasma was collected from patients before and directly after treatment. At baseline, plasma samples were collected at the same time from 48 healthy, age-matched female neighborhood controls. A panel of 92 inflammatory markers was determined in parallel in 1 μL samples using a 'proximity extension assay' (PEA) based immunoassay. Since Transforming growth factor beta (TGF-β) and interleukin-1 receptor antagonist (IL-1Ra) were not included in this platform, these cytokines were measured with ELISA. In CFS/ME patients, the 'normalized protein expression' value of IL-12p40 and CSF-1 was significantly higher (p value 0.0042 and 0.049, respectively). Furthermore, using LASSO regression, a combination of 47 markers yielded a prediction model with a corrected AUC of 0.73. After correction for multiple testing, anakinra had no effect on circulating cytokines. TGF-β did not differ between patients and controls. In conclusion, this study demonstrated increased IL-12p40 and CSF-1 concentrations in CFS/ME patients in addition to a set of predictive biomarkers. There was no effect of anakinra on circulating cytokines other than IL-1Ra. ClinicalTrials.gov Identifier: NCT02108210 , Registered April 2014.

Twitter Demographics

The data shown below were collected from the profiles of 29 tweeters who shared this research output. Click here to find out more about how the information was compiled.

Mendeley readers

The data shown below were compiled from readership statistics for 35 Mendeley readers of this research output. Click here to see the associated Mendeley record.

Geographical breakdown

Country Count As %
Unknown 35 100%

Demographic breakdown

Readers by professional status Count As %
Researcher 7 20%
Student > Master 5 14%
Student > Doctoral Student 4 11%
Student > Ph. D. Student 4 11%
Student > Postgraduate 3 9%
Other 6 17%
Unknown 6 17%
Readers by discipline Count As %
Medicine and Dentistry 8 23%
Nursing and Health Professions 4 11%
Neuroscience 3 9%
Psychology 3 9%
Biochemistry, Genetics and Molecular Biology 3 9%
Other 5 14%
Unknown 9 26%

Attention Score in Context

This research output has an Altmetric Attention Score of 16. This is our high-level measure of the quality and quantity of online attention that it has received. This Attention Score, as well as the ranking and number of research outputs shown below, was calculated when the research output was last mentioned on 09 April 2019.
All research outputs
#1,171,278
of 15,223,481 outputs
Outputs from Journal of Translational Medicine
#172
of 2,874 outputs
Outputs of similar age
#45,990
of 404,400 outputs
Outputs of similar age from Journal of Translational Medicine
#21
of 260 outputs
Altmetric has tracked 15,223,481 research outputs across all sources so far. Compared to these this one has done particularly well and is in the 92nd percentile: it's in the top 10% of all research outputs ever tracked by Altmetric.
So far Altmetric has tracked 2,874 research outputs from this source. They typically receive a little more attention than average, with a mean Attention Score of 7.5. This one has done particularly well, scoring higher than 94% of its peers.
Older research outputs will score higher simply because they've had more time to accumulate mentions. To account for age we can compare this Altmetric Attention Score to the 404,400 tracked outputs that were published within six weeks on either side of this one in any source. This one has done well, scoring higher than 88% of its contemporaries.
We're also able to compare this research output to 260 others from the same source and published within six weeks on either side of this one. This one has done particularly well, scoring higher than 91% of its contemporaries.